I've started another thread about COX-1 inhibitors since they help to minimize PEM (though not completely block it) for me. A couple others have...
The main issue would be setting it up so that you end up triggering PEM in a way that is somewhat consistent across participants. You could of...
Thanks all for the discussion so far, it's been really interesting to read. In my view, it is of high importance to find a biomarker for active...
My worry is just that researchers would not know this is something that the community offers to do unless they’ve been here long enough to happen...
Side note, is there any sort of document that outlines patient recommendations for researchers. Something that might address best choices for...
I think at most they would have gotten into a very obscure journal that no doctor reads. But maybe that's the pessimist in me. Added: if they...
This study does basically mirror the improvements I see on vyvanse (dextroamphetamine). I was surprised when I joined ME/CFS communities that...
I think there is some utility to this paper for the not-insignificant number of doctors who might know that activity exacerbates ME/CFS but still...
Ah my bad, I got too excited answering a statistics question and haven’t seen those threads yet. Even among biologists who have been in the...
Thanks so much for sharing! Microglia is exactly the hunch I’m onto as well (and other non-brain-specific macrophages). If it is...
This study occupies a bit of a gray area. Multiple hypothesis testing is most applicable (though not exclusively) in situations where you’re...
This discussion has been split from Physical function and psychosocial outcomes after a 6-month self-paced aquatic exercise program for...
Looking at the tables they actually did calculate between group differences pre and post intervention (separately for each timepoint). That would...
I suspect multiple testing correction wasn't done because each outcome was treated as a separate hypothesis, and trying to reduce the rate of type...
So the important follow-up questions for the study are: What are the temporal dynamics of PEM among the whole cohort? Are there distinct groups...
I suspect some of this goes back to an ongoing discussion I have seen on other parts of the forum: does delayed PEM have different biological...
Yes it is! Sorry, I must have copied it wrong trying to do it in my phone.
It's very much up for debate--I did a deep dive on it about a month ago when I was searching for citations on that claim for a LC publication....
upon further research, it appears that CO poisoning symptoms can also partially be attributed to lactic acidosis due to impaired OxPhos and oxygen...
I believe the main study showing that severity and LC risk are correlated is one of the Al-Aly veteran's center studies. Several others since then...
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