Hutan made a correction after paulendat's comment and it looks like everything else is correct to me
My intuition keeps pushing me to the idea that metabolic regulation in innate immune cells is precisely that "railway switch". It seems that...
My bad for misleading you @V.R.T.!
Having read the full paper now I’m a bit disappointed that they only examined PBMCs after external administration of the Lyme peptidoglycans—I had...
The idea would initially be at baseline w/o PEM—I’m fairly confident that at least some signature can be picked up outside of PEM. I’m not...
At the moment I only have speculation with a lot of unknowns. My suspicion does not rely on autoimmunity. Rather, I'm tossing around the idea of a...
Was not suggesting using it as a therapeutic! Just wondering aloud about potentially using co-IP or another method to determine if there is...
Ah thank you, I misspoke. Yes I'm familiar with the pathway from a rotation professor that was interested in CRISPR screens of homeostatic...
I've just read the abstract so far, but if the findings are solid (and I generally trust this journal), this is a BIG finding. Unfortunately it...
macrophages come from monocytes! (if they're not self-proliferating tissue-resident macrophages)
IRG1 encodes the protein that catalyzes itaconate production--they did an IRG1 [edit: knockout] to see if interferon beta production is dependent...
To paulendat's earlier point, I've found this paper: https://www.nature.com/articles/s41598-020-80933-7 Which shows that endogenous itaconate...
As in knocking down a specific gene in a cell line or mouse to see how it functions without the protein from that gene
It's a potential PhD thesis. My work would be focused on the multi-omic integration part, since that is what I've already been working on. The...
Preferential glucose sequestration by greedy activated macrophages?
I seem to have a habit of arriving to a new topic (for me) and coming up with brilliant ideas just before reading the paper that spelled it out...
If he's speaking about the macrophage itself shutting down then I think that's where the hypothesis would need to be amended--macrophages become...
I for one am open to the idea of an adaptive immune shift, though I think metabolism is the link that could define a positive feedback loop. Given...
It's not inhibiting it's own metabolism per se, but rather shifting towards glycolysis which can be mobilized much more quickly, even if it is...
Thanks for the clarification--I'd be really interested in your verification. If it's true that it is not a potent enough SDH inhibitor, I'd be...
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