Those are all great points, though I wonder if that's something that would be addressed anyways through an in-depth interview. The point of...
I’m taking 400mg at a time for the malic acid so yes I think what you have would be enough to tell if it works for you. [edit: malic acid would...
Please keep pointing out problems! I may be better than your average clinician/researcher at spotting problems (it’s a low bar) by virtue of...
I appreciate the questions since it helps me flesh out this idea more :) From seeing discussions on this site I think there actually is an...
It’s likely that DecodeME results will be out before I have a chance to put this together anyways, so I definitely will. However, it’s very...
Mostly it’s a matter of finding homogenous study groups in the absence of a clear marker which defines all ME/CFS (if that exists). It makes it...
That would be great if possible, it would just be a matter of whether the data collected, on either the sample or patient reported outcome side,...
Yes I had this thought—it could be adapted for severe (though possibly not very severe) by being an interview over text or through email link with...
https://www.sciencedirect.com/science/article/pii/S2772892724000798 This review mentions that itaconate import has been observed in both T cells...
Thanks for letting me know! I think between me, you, and one other friend I’ve been chatting with privately, it seems consistent that malic acid...
Something I’ve been tossing around as a potential dissertation idea is to start with a broad group of individuals who have been diagnosed with or...
I don’t want to push it on anyone but since you already mentioned you’re looking:...
Absolutely! I wish I had access to a community of others pointing things out like this when I was first starting to learn immunology on my own...
That’s one of the things associated with aging. My former rotation lab also did some interesting work associating the length of a gene with...
No no you’re doing a great job—just wanted to point it out because this happens to be a field where the terminology can get so incredibly...
Thanks for putting together all these resources @hotblack! Just a quick note about the cytotoxic label: while generally it does refer to...
I haven’t had a chance to read the full paper but it’s interesting that the DHEA finding was replicated with my team’s LC paper, which also has...
For what it’s worth, some of my literature search turned up that the itaconate response can be triggered by interferon gamma as well. Meaning that...
I’ve been having the same line of thought—what is interesting to me is that succinate dehydrogenase (one of the TCA enzymes affected by itaconate...
That’s what we’re here for :) Explain like I’m brain-foggy: The baseline ability of the brain to carry out cognitive tasks is unchanged (CPU),...
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