It’s interesting that you mention that—the only times cognitive exertion produced PEM for me was when I was more severe than I am now and I was...
I think I am just struggling to reconcile a theory that does not take exertion into account with my experience. If it was just neural signaling...
Almost exactly what my PI said to me re: my malate hypothesis :) I started by trying to hypothesize what might be a constant difference in pwME...
Specifically, in my theory, it would not matter even if it is a relatively small cost. It would be a combined factor of the degree of increase in...
I’ve been looking into this question recently as I’m decently acquainted with both neuroscience and cell metabolism but not an expert in either. I...
Okay, at this point, I think it’s just going to go in circles forever.
It does come from the DNA to an extent—for example, for T cell negative selection, cells in the thymus are able to actually produce proteins that...
Ah my bad, my (mis)understanding was that molecular mimicry theories always involved some ex-post-facto "override of the veto", as you put it....
The process I have in mind is: 1) Virus infects host, virus has several human-lookalike proteins including viral protein X that resembles human...
@Jonathan Edwards would it be possible to have a response triggered by weak antibody binding to self-antigen from an antibody that was initially...
[edit: removed part of my answer that was just me completely misremembering a part of negative selection so as not to confuse anyone] Though I...
It would mean that the same antibody binds to both. This is a theory of autoimmune disease that has been around for a while (most recently, in my...
Gosh, well normally I'd have no problem but there's this pesky issue of my body not really working properly. Gosh, well normally I'd have no...
The perceived stress scale used in the second study is full of questions that assume two people taking the test will have a similar functional...
Again, BPS studies seem to have no problem recruiting for study after study. The issue is that those studies are repeatedly low quality despite...
Great! Then I would love to see good quality evidence that chronic psychological stress is the driving factor of illness for some, or even most,...
This doesn’t address the point I’m making in the quote at all. In my view, the ongoing issue across all the responses I’ve seen from you is a...
From the original paper: “Daily count” appears to just be general movements that would register as a change in velocity on an accelerometer....
I had the same question. I’m guessing they were using DSM IV criteria, which came out in 1994: So….excluding probably everyone who might have met...
Even if stress is a factor in precipitating one person’s illness, it doesn’t follow that stress reduction will necessarily have any substantial...
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