I have a monoallelic frameshift mutation in the PER1 gene which is part of the the clock machinery that creates circadian rythms in the brain and...
A big factor is probably how rested patients are and how long ago the last significant exertion was. We already know that exertion causes...
Language that is intended to mislead readers with little expertise, and obfuscate rather than provide clarity, is so typical of psychosomatics. It...
From what I understood the liver has its own circadian rythm that is influenced by and influences feeding and fasting behaviour. I learned about...
TORC1 is described as stress sensor. And it influences autophagy. At least one research group has reported abnormally elevated TORC1 activity,...
The pretense that LC is totally new is a way to get research done without upsetting people that are invested in trivializing and psychsomaticizing...
Re. sodium. There was this study that found increased sodium content in ME/CFS muscle and the authors believe this is due to a dysfunction in the...
Some recent findings implicated abnormal autophagy in ME/CFS. Autophagy seems to fit with delayed PEM, the idea of cells being under major stress...
My impression is that replication attempts and successes have increased. They findings seem much less "all over the place and unreplicated" as was...
To me it seems like some progress is clearly happening. We're seeing more marked abnormalities being published, and ones that fit with previously...
Sales of SSRIs reaching record levels because they're being prescribed for people who have all sorts of other kinds of life problems like poor...
On the function of NUPR1 This suggests circRELL1 is an indicator that cells are undergoing significant stress Edit: or maybe that sensitivity...
In my opinion a good approach is to try different things and create your own routine based on what feels good for you. If it makes you feel good,...
The premise of this paper is strongly at odds with my experience. In some ways, almost the opposite. The narrative is that of a patient that is...
I found this bit interesting because it's hard to predict, from how my body feels, how long I will be able to sustain an activity. I often feel...
"ME/CFS" is the new name for CFS and for ME. CFS was the new name for ME.
As is the case in hundreds of other diseases? :rolleyes: These other diseases mostly don't have a psychosomatics lobby group that is constantly...
I think what the authors and many others are doing is confusing cause and effect. When we are sick, the body adopts a survival program that is...
Looks very interesting. I would love to have a device that can track blood flow to the head. It would probably help me get treatment.
Maybe the NIH is taking so long because they think that due to the controversy surrounding ME/CFS they need really solid evidence before making...
Separate names with a comma.
