I don't seem to get PEM from cognitive exertion but I do get a bit foggy in the evening sometimes. I wonder if it's PEM in disguise, but like...
In an open-label trial, why do you think that subjective outcomes are merely 'not ideal' rather than fatal? You seem to be putting some sort of...
I want a cure, so how can we start a new school of thought? I'm sorry to hear Jo isn't well. I'm sure we all appreciate all her hard work for us...
I'm the only one to have called it the Grand Theory of Everything because that's what it is in my head but it may well not be one!
So you keep saying, and we keep pointing out why you can't trust subjective measures in open-label trials. Is there something that you disagree...
And do you agree with them? And if not, why not?
We've just been talking on the PEM factsheet thread (most recently starting here) about the need for a thread specifically on this issue of...
Thanks, @Yann04 - I don't doubt that the brain is doing some processing but is it doing 'a lot of work' in the sense of 'expending a lot of...
The Internet (vague, but I'm feeling lazy) says we burn about 50-75 cals/hour just lying down and resting. Google's AI summary thing says, 'The...
I have the impression that you haven't read @Jonathan Edwards's expert witness statement, @dundrum. It's here, starting on p.5. I don't think it's...
@dundrum, relating to harms in PACE, again from Wilshire et al.: The adverse events measures collected during the trial included: serious adverse...
@dundrum, relating to the 6MWT in PACE, this is from the critique of PACE by Wilshire et al.: A number of other secondary outcome measures were...
Graded exercise therapy has not been shown to help. It has only been tested in open-label trials, and we have explained to you why subjective...
Why are other limitations and biases not enough to junk a study? For example, an open-label trial with subjective measures, where you can place no...
My bolding: Do you mean that if all we have is poor studies, we should take their positive results at face value because that's all we have? If...
Is it dangerous? It doesn't sound like a very attractive treatment to be on the receiving end of.
You've given reasons that you believe to be logical but you don't seem to be taking in the counter-arguments, such as the one I just made....
Fair enough but this is the fundamental issue and the reason why you're finding no agreement with your position here. But 'mitigated to a...
You may not have seen my post earlier in the thread where I asked you if you accepted that you can't rely on subjective measures (people saying...
I may not have understood the context in which you're framing this but so many PwME are disbelieved about their illness, by everyone from family...
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