There's a lot that isn't covered by the available methods of brain imaging. I'm not sure what the smallest range of chemical signalling is, but I...
Yes, on PR, several other members stated that they didn't get physical limiting symptoms either. Some of them continued what sounded to me like...
Nope, haven't found anything like that in journals. It's just my theory based on observations of my PEM in response to exertion. Earlier today (...
Unrelated plant. No cuminaldehyde.
No, I used several no-name packages of ground cumin, and bulk seed from at least two different stores, and they all worked the same. Some exotic...
Repeated testing, while holding as many other variables as possible constant. With the cumin, I found a list of compounds found in it, and tried...
Maybe because brain cells are hard--and expensive--to scan in high detail? It's hard to measure how tightly astrocyte feet are clamped around a...
I wonder if stress is a factor in that. Reading a technical document for self-education doesn't involve emotional stress, so it doesn't trigger...
That's true as far as I know. I found that in one or more papers. I think it's normal for activation of the body's immune systems (t-cells,...
I'm not sure how you can know that, since it would be hard to tell when the virus starts replicating enough to trigger the immune system. Also,...
No. I did have a brief period (few months?) where I had what might have been OI (abrupt exertion would drop blood pressure in my head), but that...
I voted 'yes, after exertion', but I'm not entirely convinced that it's due to ME. My sleep seemed normal for the first decade or so of my ME,...
I didn't answer the question about refreshing or not refreshing because I think my sleep refreshes what it normally should, but ME gives a...
I voted for 'no effect' since eating in general doesn't affect my symptoms. That's ignoring certain (all too many) foods that I have a bad...
A couple of years ago I discovered that cumin (cuminum cyminum) was very effective at blocking my physically-induced PEM (didn't affect...
I think it's possible that some PWME could sustain permanent damage, but I think that's not typical. I can't even estimate how many PEM episodes...
My theory on PEM is that it's a neurological switch of some sort. Cognitive exertion can trigger it directly, with minimal delay. Physical...
I use the terms "physically-induced PEM" and cognitively-induced PEM".
No, there can be such a switch. Physical exertion triggers an abrupt rise in IFN-g ~24 hrs later, and that cytokine can trigger all sorts of...
To answer the original question, I believe that PEM, and ME overall, arise in the brain, with metabolic problems in the body as common--but not...
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