two month update: feel quite a bit better. Absolutely unable to confidently tell you if it's the shark liver oil. Lag is a real issue with...
Interesting!! One of the non-canonical causes of UPR (alluded to above) is a failure of calcium homeostasis in the endoplasmic reticulum....
Yes, hi ! Not currently but in my most mild periods this is how my mecfs used to remind me it was still lurking. I'd come home from a bike ride...
This is such a weird quirk of the disease. If I cross some invisible threshold I get slammed later. It's a massive clue. I previously knew of...
I'm always pleased when I see Whitney Dafoe posting online because it suggests he's feeling a bit better. His blog is chugging along recently and...
:emoji_tea::emoji_tea::emoji_tea::emoji_tea::emoji_tea:
I just want to point out that these kind of -omics studies are still coming! Bergquist and Armstrong are going to drop a really detailed study...
Another interesting slide from the same talk, 1h24 mark. [ATTACH] Seems to show that a rise in succinate during exercise correlates with mild...
INteresting slide from video 2. Via an American researcher called Singh who works in concert with David Systrom. They made two subgroups out of...
There are some great points here about the limits of knowledge. I want to describe how I see it. We know most studies cover only a fraction of...
Here's another one while I'm on a roll. Naviaux vs Fluge 2021. This is the Fluge paper where they run some unsupervised machine learning to create...
This next chart compares Hanson 2020 to Naviaux 2017. There's not loads of metabolites in common but the ones I found in common do not show strong...
1. This is so wonderful to see, thanks heaps for your hard work! my dream with this project was the many impressive people in this community would...
Great work @chillier ! :heart: i want to come back and respond to that but first I will post the data and code for the analysis I did above. So...
Getting organised to submit an FOI request is very much not my skillset but trawling through 1000 pages of correspondence looking for a smoking...
Excellent diligence, Lone wolf! I respect your grind a lot.
This is an excellent question. We can cut it by significance and we should. I'll try to do it myself at some point soon but if someone else wants...
One possible thing we may be able to point out is that untargeted metabolomics delivers no consistency in findings and isn't worth pursuing. In...
I'd like to shout out to a couple of inspirational projects for this kind of meta-analysis. Brydges, Che Lipkin &Fiehn 2023 and Kaczmarek 2023....
So this is some code for analysing the Hanson 2022 data. https://github.com/jasemurphy/mecfs/blob/main/Hanson%202022.R and this is the data...
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