That's quite a good blinding technique, and a decent result! I'd like to see more data but it certainly appears as though Malic acid works for...
Been thinking a lot about cerebral blood flow, which is plainly impaired in POTS. I'm fascinated by the comorbidity of POTS and me/cfs. Could...
This is a fascinating hypothesis. Are there other types of tissue that serve as reserve energy? As I understand we use up phosphocreatine, and...
At the risk of being pedantic on the any .... Hwang's study on the patient with Li Fraumeni and mecfs showed this. "Measuring the regeneration...
You have to love when vague, general pain symptoms end up having an identifiable neural basis. Another one taken from our old friends the...
love it. I'm all for exploration of samples that are easiest to collect, least invasive, easiest to send by mail. That's how you cut costs and...
I found that survey to be a bit of a pigsty. Didn't ask any questions that might have got information from me, and I have quite an extensive...
Emerge ran a competition for the best story about Long covid. the winner was Hayley Gleeson, published at the ABC:...
I'm keen on this kind of basic epidemiology, I have suspicions that populations are not equally prone to me/cfs even after controlling for...
Very nice explanation. You're an asset to this forum, thanks for all your contributions!
authors: Stanford Journal: PNAS. cases: 650 controls:661. p-values: some very low indeed. tl;dr this study is more likely than most to have found...
This idea of heteroplasmy could also be relevant to mecfs: you need have the genetic problem in only some of your mitochondria for symptoms to...
Whenever I read about people having problems with the various complexes in the mitochondrial chain I think about Hwang and WASF3. He found in his...
Got excited by the title, but this is a single author hypothesis paper. To stand up the hypothesis will require a bunch of funding.
Doesn't look like too much to me? They checked 94 million genetic variants in patients, found 398 differnt mitochondrial ones in patients, there...
There's lots of known unknowns in this space like plasma vs serum; pbmcs vs skeletal muscle; sample storage; collecting samples at different times...
I emailed Walder and he said : "No drugs yet from the me/cfs study, should be finding some later this year if all goes well". He understands as...
Look, I also don't think this is the research process most likely to lead to a cure. I do find myself attracted to a philosophical approach that...
There's a small blurb here about the work Deakin are doing on me/cfs: https://med-projects.deakin.edu.au/projects-2023.php [ATTACH] [ATTACH]...
I don't want to become the defender or spokesperson for this technique, but it does proceed based on that premise: we dont know what's wrong, so...
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