This. The Hwang paper does not suggest a genetic cause for elevated wasf3. It suggests it is downstream of endoplasmic reticulum (ER) stress....
It's all just in the original paper. They built a transgenic mouse with extra copies of wasf3 and found it was crap at running. tbh my memory was...
This looked exciting but I watched the corresponding segment and it seems to be that bh4 is 39% in a single mecfs patient, and Ron implies it's a...
Just to add a positive note.:nailbiting: I think this study is awesome. It validates, in an enormous cohort, that you can be sick as hell even if...
Creating a baseline of data on what healthy and unhealthy bodies do under exercise is going to be really useful. The timeline they have there is...
The just world fallacy goes like this: people who get sick are the ones who, at some subconscious level, want to. it's an extremely comforting...
I'm posting this one because I've never seen hypoxia responses linked to circadian issues before. But they are, the paper claims, linked. There's...
Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome Vaishnavi Dandavate 1 , Nityanand...
One of the metabolic pathways we use, right at the start of actvity, is Phosphocreatine. It's used before the body can get normal metabolic...
it's not the sort of ultra cure you might hope for when matching a treatment to a defined subset. And with people whose course of illness is...
Well, 1. there's a lot of the body outside the mitochondria. most diseases find their cause other parts of the body. e.g. for us maybe the...
Fascinating little paper. TTMV9 is an anellovirus. Wikipedia says: "Their virome has been present in most humans. They enter in the cell early...
I've noticed I react strongly to food made in a slow cooker. Even if the ingredients should be on my fodmap safe list. I now suspect that could be...
I've experienced hypoglycaemia related to rapid gastric emptying before. It usually follows a very specific pattern that is quite rare for me now...
I've had fodmap sensitivity for ages. I blew up one of those hydorgen breath tests and got a record score, suggesting my body wasn't coping well...
Fairly simple technique used. Pull out some PBMCs and run them through the Seahorse machine. Then create this BHI index based on the numbers it...
I recently ran a self-experiment, reducing my beta-blocker dose for several weeks before reinstating it. The effect was noticeable within days....
It's an antibody, available to researchers. Quite expensive at $1486 for a milligram: https://www.antibodysystem.com/product/8926.html Perhaps...
In the most excitable parts of the longevity research community they talk about "escape velocity". You live long enough to be there once the...
I should add that not only are the benefits visible in mice engineered to be low in IL-11 but also in mice given anti-IL-11 therapy once they were...
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