I'm not sure. The mechanism I was talking about involves spinal feedback loops related to proprioceptive afferents.
Neuropathic pain conditions are due to incomplete recovery of damaged nerves. Often this is due to peripheral neuropathies (they usually arise...
No one can even agree on what the perception of fatigue actually is. Is it an altered perception of effort? Is is unusual muscular pain or...
I'm not sure why they thought there would be a difference, but better to know than not know, right?
I don't think that is true when the medication is something really obvious like melatonin. But I agree with you all, that this is a weak result.
When people make claims like "100% have hypocapnia", they lose credibility to me. Markers like this never have 100% sensitivity, I doubt he has...
Except that it often doesn't. Many fibro patients have normal pain threshold responses to various forms of stimulation. Also notably, NK1...
In other words, they don't have a clue. Despite all the media hype, the vaccines don't seem to have much effect for most LongCovid recipients....
If only that were entirely true... Questionnaires are the basis for much of "Evidence based medicine" (and psychology).
Given that the spike protein itself is almost identical between the mRNA and Adenovirus vectored vaccines, the main differences are the...
Transient central sensitisation, measured as secondary hyperalgesia can be induced through capsaicin (or other TRPV1 receptor agonists)...
In general, conduction velocity is supposed to increase with higher activation threshold/higher force output and thus is associated with greater...
Long term, I suspect the efficacy of the second dose at both intervals is probably the same. In the short term (3 months after the second dose),...
Here are some correlates of increased conduction velocity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192232/?page=8 (decreased rise time,...
Note, the sample size isn't huge, so there is some uncertainty, but the efficacy against any PCR positive result (asymptomatic + symptomatic) was...
I'd expect the effect to be similar. I can't remember the link to the video, unfortunately.
Vaccine efficacy in aged care in the UK https://www.medrxiv.org/content/10.1101/2021.03.26.21254391v1.full.pdf Around 62% efficacy against...
I'd argue, yes, the question is how well? The AZ vaccine was at least in the 50% range for efficacy against asymptomatic + symptomatic infection...
I can't guess the reason. The adenovirus based vaccines aren't significantly less 'reactogenic' than the mRNA vaccines.
There are "traditional" vaccines too, Novavax which is a subunit vaccine and CoronaVac from Sinovac, which is a inactivated virus vaccine. So the...
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