Well that is the question. But then when you have widespread muscle pain with influenza or a typhoid vaccination there isn't any inflammation in...
I have no idea. I am just going by rumours from journalists.
I am thinking that we are going to get some major front bench resignations and we may end up with Ms Reeves changing jobs. This is almost as...
It's another aspect of the muddled thinking since 2000. We separated out all sorts of different macrophage states long before that - crucial to...
Patients. Friends. Arms, legs, MRI scans. Cytokine milieus aren't inflammation. I know that has become the fashionable way to look at things but...
Yes. Which makes the point that there isn't going to be a single answer that fits all. It looks as if we are looking for multiple interacting...
I don't get the impression it is that rare. I have read accounts of people suddenly feeling better dozens of times on the forum. Some people have...
Trouble is, that is sort of circular if ME/CFS is at present simply the group of people who have a symptom pattern.
But do we have evidence for this 'ROS generation'? Or damage from it? If this is the story why has nobody picked it up on MR spectroscopy of...
I am happy that there may be changes in metabolism but that does not imply that the ATP availability is actually inadequate in a way that might...
But there isn't any inflammation !! What is a 'pro-inflammatory' phenotype anyway? The jargon in this area seems to me to have wandered away from...
But I don't see that fitting with the time course of PEM. Once PEM gets going people are often kyboshed for hours or days - or longer. The...
I think is a pretty good test. It means that permanent shift due to bine marrow cells learning something cannot account for ME/CFS in every case....
I think that is an excellent point.
I doubt it is wrong - same old paternalistic stuff.
I agree that at least some studies suggest a diversion of metabolic pathways. But, like Mike Murphy (mitochondria, Cambridge, UK), I am sceptical...
I can only agree that the last few posts are asking the right questions. I have a thought about what this stuff might mean but it will be about...
Do we really have good evidence for inadequate ATP generation in ME/CFS? As I understand it Audrey Ryback's attempt to show altered metabolism did...
That would be a much smaller group to handle. Test like this very often lead to bad judgments, yes, but all medicine is doneonthe basis of...
Well, for a start, if the patient is normal and healthy without any pain then the test is unlikely to be providing information about the pain they...
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