Yet that is exactly the view of researchers in the field. They cannot personally think of a better way, so they assume their inadequate trials are...
Notably, there has been no studies that actually ask patients which outcome measures are most relevant. Likewise, none of the PROMs have been...
Horton is rushing out a book on COVID19 this month. I'm trying to remember what he was saying about travel restrictions and other COVID related...
Apparently (according to Richard Bentall) I'm profoundly ignorant as I believe that a lack of patient blinding can lead to response biases when...
No one wants to point out the emperor has no clothes because it means we would necessarily throw out a lot of evidence for non-pharmacological...
It's also important to consider that there is a difference between placebo effects and reporting biases. The former would be actual reduction in...
Indeed, torturing mice with forced swims might cause fatigue, but it certainly isn't CFS or ME. Side note: Heme oxygenase is HSP32. Heme is...
The "compromise" is to simply lump all studies that don't meet basic quality criteria into a "low quality evidence" basket. If all studies fall...
Isn't that kind of arbitrary? I mean any highly specific criteria is going to need sufficient scientific justification and I cannot think of any...
If the "pivotal" study was actually excluded because it was of low quality, eg unblinded comparison groups, did not use objective outcome measures...
I believe you are referring to the "original antigenic sin" hypothesis? https://www.jimmunol.org/content/202/2/335
September? Why even bother at all!?!
I wonder if this can be used to estimate disease burden weightings?
CD4+ T-cells are supposed to have some degree of cross reactivity with the viral proteins, even without prior exposure, otherwise the adaptive...
Further on the topic of "asymptomatic", The Chinese authorities claim they have tested 9.9 million people in Wuhan!!! They claim 300 positive...
I was never a coffee drinker before I was ill, but I've always found it to be counter productive. It counters drowsiness, but it can make it...
Continuing on with what Michiel mentioned, the full quote: Mhmm... Which means the "symptom amplification" hypothesis (that attentional bias or...
JB Handley is also a vaccines-cause-autism guy.
That is a modelling study with far too many questionable assumptions. As such, it is important not to confuse pre-symptomatic and individuals...
Yes, participation biases, a desire to please the investigators, and the fact that this is not an unheard of explanation can lead to an...
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