But I do not understand that. We have no idea what significance 'brain fog' has over and above the symptoms themselves. There is nothing to...
Excellent questions. It is very unlikely that antibodies made using VH30-3 are specifically damaging. Indeed it is not clear that anything causes...
It is good to see people interested in research related to ME/CFS. But my question would be why asking abut internet use would help providing...
This relates to my last post. We agree that terms like PEM and brain fog tend to be things, like synovitis, or subluxation, that doctors and...
I absolutely agree and hopefully that will be clear when the video of my recent seminar presentation is made generally available. The fault is...
I don't know but I don't see why it should have anything to do with ME/CFS? There is no general observation of a link between ME/CFS and swellings...
I agree, but some things are so common that an association is hardly worth looking for. I had the same terrible costal pain as a student, forcing...
Yes but it is almost certainly a mechanical strain of rib attachments rather than a 'chondritis' which is almost a contradiction in terms since...
Agreed. I strongly suspect that safeguarding issues are triggered by patients and carers talking about brain fog or PEM, when what they mean are...
However, none of the proposed therapies are of proven benefit to all patients Yes, we should all really put in a plea, however much we respect...
Yes but costochondritis is a mythical diagnosis. There has been some quite nice work on costochondral pain and it seems likely that it is mostly...
@EndME, Inactivity - vanishingly unlikely Something other - confounding associations are a big worry but I think more for things like insulin...
We can rule it out. Younger is talking about glial activation which, on its own, isn't inflammation. It's just glial activation, and the consensus...
I have not been involved directly in VH usage weighting studies, although Jo C has, but it is looking to me as if VH30-3 may turn out to be one of...
That's interesting but I am not at all sure what 'down regulation' of a VH gene in PBMCs would mean. A small proportion of PBMC will be B cells....
The further problem is that steroids impact on the brain through non-inflammatory pathways too, and induce euphoria, maybe 'energy', even in...
I am sure the Melbourne team have the best of intentions here but I do agree that this is not a very well written review. I used to insist that...
No, it would be hard to do that systematically. The evidence against an antigen driven response comes I think from indicators like restricted...
Most of the paper discusses trials and I am not sure how much we can know about how well the patients adhered to GET. No doubt most people who...
I think it may point to some sort of 'gear-changing' in immune activity. It might fit loosely with ideas like a 'hibernation response' or a...
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