Hi @MelbME I can see the value in doing a well-designed trial of saline infusion, if only to show that it doesn't work, which I think is the 95%...
I think they say they used 800uL of serum from each patient. It shouldn't have been hard to get 6.4ml. Pooling serum actually degrades the...
Isn't there a n FND society, probably run by Jon Stone, though? Sharpe has the support of the Royal College of Psychiatrists and even the Royal...
In a sense maybe, but what we normally call research is investigation that reliably transfers to a general situation. And when it comes to the...
Hi @MelbME. Is saline beneficial? Standard physiology would suggest that the chances of saline infusions being more use than drinking a pint of...
Yes I agree absolutely on this, but it need to be done as a research exercise to see what predicts what.
The monitoring should be possible, but what would you do with it? For asthma and diabetes we have well documented treatments that provide...
Not a bit of it. That is exactly what we have been discussing on threads here for years!!
Detailed recording ought to be useful for research but the issue here is how people should be assessed in routine practice. Until we have evidence...
Now that I remember, @PeterW, we used to call it the Yak Dung Effect in the lab in 1980. Give a mouse or a rat anything and the graph will shift...
I think it much more likely that it was very sensible and that a new generation of researchers will repeat the mistakes of the 1970s and 1980s....
If it was a good model I think drug companies would have sorted out the methodology and been using it for screening drugs for decades. The...
It is hard to wade through it all. Two things I noted: They pooled sera. That seems to me a disaster. If you pool 8 sera and give them to 8 mice...
Having once been an 'animal model authority' I am pretty sceptical about findings like that. There are so many things that can affect your...
This would be my main concern right from the outset. There is no point in having an information sheet that sounds right to patients but which...
I would contrast this paper with the sort of paper that one found in a journal of 1974 - where a single simple experiment was reported and in six...
Loss of smell/taste from drugs and infections often continues long after the cause has gone. My understanding too is that is often the case for Covid.
So taking cells out of your left arm and putting them in the right does nothing, as expected. There is no way this is a 'placebo response making a...
Yes, I absolutely agree with that. (I have read the whole thing.) The tone seems counterproductive. And I agree that 'early intervention tube...
But where did the 'effective therapy' come from. The 1998 article by Chalder and Wessely (?David) describes the detail of how CBT for CFS should...
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