I don't think you would need to go to South America. Levels of exposure to environmental factors are likely to vary hugely nearer at home - either...
But none of those conditions has anything much to do with environmental factors as far as we know. Smoking predisposes to RA but the others seem...
Except that we don't have any epidemiological patterns to fit with that as far as I can see. There ought to be hot spots.
I think a lot of these arguments could be applied equally to the autoimmune and auto inflammatory diseases. Interestingly, it seems that most of...
These are all relevant questions to ask, but the causation of disease is more complex than just bad genes and environment. A major third class of...
Old age.
Well, the continued existence the CAR-T cells would be responsible for the continued B cell depletion to some degree. It is not clear quite what...
I don't see plasmablasts as having much role - they are just a transient state in blood. I presume the antibodies continue to go down because...
It is interesting that almost nobody came back to the thread and expressed enthusiasm about Unrest as an educational tool. I see that I said...
The Wikipedia entry on pragmatic trials is informative. It is also intriguing to see that in this sort of case entries are always written by...
The pragmatic trials unit at Queen Mary says: What is a Pragmatic Clinical Trial? Schwartz and Lellouch were the first to use the word...
Looking at the author list this looks pretty much like a scam advert.
I am not aware of mesenchymal stem cells being of any value in inflammatory or autoimmune disease. Is there any evidence? Autologous stem cells...
The other point is that the blood text mentions randomised trials, and as we saw with PACE, randomisation isn't actually what makes a trial...
I haven't looked at the paper beyond the abstract but this sounds like special pleading, as you say. There is a very simple solution to the...
Maybe it's TGFbeta after all. It was the one cytokine to actually show up in some studies. It is a mediator of repair and tissue strengthening....
There is something about Nath's comments that reminds me of Fiona Watt at the MRC 'How awfully shocking that you should be disappointed in our...
We targeted the B cells in RA because we have worked out all the steps in the mechanism, including why B cells are specifically suited to colonise...
That was what we tried to do with combinations early on but soon realised that we did not have the tools to break through. I have been trying to...
Yes, but quite a lot is known about signals from infection and exercise that will impinge on the brain - through hypothalamus mostly. The brain...
Separate names with a comma.
