Tronstadt's group do another metabolomics study in a 2021 paper, and don't really replicate their 2016 result in their whole ME cohort but do...
The muscle metabolomics done by Rob Wust's team in long covid would fit fairly well with that: [ATTACH] If glutamate and alpha-ketoglutarate are...
I'm quite pleased to see these changes. I would still prefer if the link text itself referred to mecfs rather than cfs, but the most important...
Moved posts I think there was a thread about this but I can't find it so posting here. I think the NHS website for ME/CFS has been improved....
The amino acid results in Tronstadt's 2016 paper seem to be pretty much a female only effect. Interesting! I don't know unfortunately, maybe...
So true! I can't imagine what would happen to me if I did a CPET. Must be dangerous for so many people. Maybe something like longitudinal sampling...
Good point about group 3. Group 2 generates acetyl CoA but group 3 don't so you would expect levels of oxaloacetate/ malate to increase and...
My concern with the amino acid findings in Tronstad 2016 is that it doesn't seem to replicate very well. Amino acid differences are not really...
This thread's paper also relies heavily on Gene Ontology (GO) term enrichment analysis, which Grimson et al also do. Gene Ontology terms are short...
The Grimson paper is much better powered (n~30 per group I believe compared to n~4 here). The two papers disagree in the abundances of immune...
I believe it was a 2 year gap though that's long enough that the actual relevant series of events could be different to how I perceive them to be....
In Armstrong et al 2015's metabolomics study (n=34 patients n=25 controls) in ME the only significantly elevated metabolite they see in the blood...
Here are some of the pieces of relevant literature that I am aware of: Beentjes and Ponting's recent preprint of blood factors in the UK biobank...
I bought a continuous glucose monitor a while ago thinking it could be interesting to try. @TamaraRC 's post has inspired to me to finally put it...
For me it's as simple as this. When I was moderate but still unable to work/study early in my illness I was mostly sitting. When I'm severe lying...
Great clip really well communicated, which is difficult to do. My only suggestion would be that it's not so much it is/was thought to be...
@TamaraRC you have a slide about glucose tolerance testing on over n=750+ by McGregor. The figure you show appears to talk of small sample sizes n...
@forestglip was 2-hydroxybutyrate significant in that study? Is it possible to get the mann whitney p value for this? I wasn't clear in your post...
2-hydroxybutyrate and cysteine were both elevated in Jason et al 2022's pre-illness data study in ME/CFS: I don't recall seeing it in other...
That's fair enough! I'll make an account in that case
Separate names with a comma.
