This looks really interesting - no individual TAG passes adjusted p<0.05, but (like with Germain 2020) they all seem to be biased higher in ME....
That's great thank you :) Mann whitney is a safe bet since it doesn't make any assumptions about distribution and simply asks the question of...
For sure, there's evidence that in general serum contains higher levels of many amino acids and differing levels of pyruvate:lactate than plasma -...
This is the CSF data if I recall right? I believe from when I looked at this earlier in the year that the ones in that heatmap are the top results...
Thanks that's interesting. They don't report on triglycerides or phosphatidylcholine in Germain et al 2020 but they do mention they are detectable...
Good point. My hypothetical plot is simply based on the cohen's d effect size value from the raw data, the sample size they report for males and...
High leptin levels seen in this thread's paper in men, was also seen in Hoel et al 2021 [ATTACH]
To compare some of the lipid findings to previous studies that have done lipidomics: This thread's paper describes low levels of...
It looks like the protein with the greatest significance for men only is BCHE (adjusted p=0.0003) which is a cholinesterase -...
Fantastic, thank you, that makes sense. : ) In that case I wonder as a suggestion if it might be good to report the units alongside each blood...
I'm not sure I agree with that. I would expect that inactivity and ME/CFS status are particularly confounded more so than the other factors you...
@Chris Ponting Thank you for your answer! [ATTACH] In this extreme example for Chylomicron concentration from fig4A, is it therefore correct...
I'm not totally sure how you're supposed to interpret the results from these direct effect plots: [ATTACH] These are reported as 'effect sizes'...
This looks like a really exciting paper I'm looking forward to properly reading through it. Here is the same table you showed but for the NMR...
As for a preference for amino/fatty acids as substrates for aerobic respiration, this was also argued in Fluge et al 2016: Lower levels of certain...
Reductions in oxygen consumption have been reported in isolated PBMCs. This is what Thomas et al 2020 reported and was the trend reported by...
@butter. sent you a DM :thumbup:
Echoing this thank you everybody for your kind words :) Not for this project. We recruited/collected from Sheffield with our collaborator...
Yes good management of expectations, and as we see it a negative result is also an informative outcome. We deserve to know one way or another....
It was a lot of fun talking with you @Simon M and quite an honour to be featured in your blog! Audrey and I have both been a big fan of your...
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