I gather there are ways of doing this on genomic data that are not based on related individuals. There's one way that exploits linkage...
1) Thank you! I'm glad you think so :) 2) I think that's basically right, just because the ones they agree on are not significant after multiple...
My understanding is the biggest parameter change is not VO2max, but a reduction in Ventilatory Threshold: The elbow where VCO2 begins to rapidly...
Interesting @Hutan and @SNT Gatchaman. Trying to get my head around what you're both saying correct me if I'm misunderstanding. [O2HbMb]-[HHbMb]...
Thank you :) They didn't do an analysis where they compared multiple datasets (from different papers). I mean that at baseline in their two day...
I've checked here using a linear model whether there is evidence for a given metabolite, that the two studies disagree in their fold change...
This makes sense about the metabolomics done at baseline but I think the two studies Hanson's group did across 4 time points over two CPETs are...
Is this comparing the significant metabolites from at least one study? Or is it comparing all of the detected metabolites regardless of whether...
[ATTACH] In this figure panel they report on one of the top 2 significant metabolites associated with the difference between the first and second...
I wanted to make a post about this paper I think it's quite interesting. I like that by having a 4 time points and a longitudinal, paired design...
I love this! I was having a look through this data anyway and a resource like this would make it so much easier! It would be great (if and when...
It's interesting to see strong positive agreement about gamma-glutamylated amino acids (glutamate, lysine, tryptophan etc) in @Murph 's...
This is cool I have a lot of thoughts about this. First thing is Hoel 2021 use serum and Germain 2018 use plasma. The metabolomes of serum and...
Great article! George Monbiot is a very good ally
Thanks for this analysis Murph! Are these metabolites here significantly different in Baraniuk 2021? I had a quick skim but in the body of the...
I noticed that in the NIH paper some of the p values they report for their metabolites are higher than their adjusted p values. This doesn't make...
Urea cycle: Carbamoyl phosphate synthesis is the rate limiting step of the urea cycle, it's formed from the combination of ammonia and...
Oh yeah very good point. I haven't gone into that myself but if @LarsSG is right about this that's reassuring. To me it looks like maybe three...
[ATTACH] Spermidine is the second most significant hit in the NIH intramural study's metabolomic data, as well as other polyamine related...
Viewing the whole thing as a heatmap might be easier: [ATTACH]
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