I have emailed Charles Shepherd.
I have only just seen this. A think it warrants an apology. Hopefully it was said in the heat of the moment.
I am thinking more in the terms bobbler is raising, that the measurements of effort choices in this NIH study aren't being taken in a context that...
I am reminded (by @bobbler and @Hutan's efforts) of the debate about incompatibility of General Relativity and Quantum Theory. This worries a lot...
From past experience @bobbler I suspect you are missing nothing. My brain is too old and my attention span too short to help but I suspect there...
I do not doubt `Cochrane's ability to bias their output, but my point was that in this particular case I don't see it as being obvious how these...
Something that struck me is that if this 'toolkit' is just for ongoing clinical monitoring then these aren't 'outcome' measures. They are...
OK, but what is the clinical assessment for? If we have no treatments that we know depend on such assessments I would have thought it more useful...
Dilutions would make interpretation a bit easier but it remains the case that at some cut off the positive rate was five times higher in patients....
Yes, that would be a classic type 2 error. So the claim that the autoantibodies were not elevated was bogus in fact. Inasmuch as it could be...
They certainly leave the door more than ajar but I cannot see this as being cited in a Cochrane review in a conclusion that says 'Even if the...
I find this very strange. As far as I know nobody as found any evidence of residual antigen and the weight of evidence in post-infective syndromes...
I doubt it. My main concern is that PWME are bound to be in a different autonomic state because they are the ones being tested for an illness -...
I am not sure that propping up ideology can have any impact on a review of evidence for efficacy of treatments. And in as much as this study says...
I am sure that happens, but an increase in symptoms and increasing debility are seen in almost any condition limiting exertion capacity. It occurs...
Indeed they have. Every study is different but the DecodeME study put a lot of effort into getting the criteria, numbers and recruitment right for...
Except that they then say it might be jolly good to add them in to the immune treatments in a nice personalised mixture dreamt up by the 'expert'...
Any disease of unknown cause that fails to respond to rituximab might do so because it is driven by long lived plasma cells. At present I think...
No that's the 64 MILLION dollar question.
Good to see this from Wust: "The pathology of reduced exercise capacity is different from PEM" I get the impression that he is someone who...
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