I very much agree. But I think this could be relevant to ME, for reasons I have discussed on the forum but maybe 5 years ago now so worth...
Do you actually have any evidence of your own to base that on? Or any published evidence? I routinely followed up over 200 patients treated with...
I am afraid that I don't get the impression that these people know what they are about!
Certainly complicated. But 4 months is a good time for maximal graft versus host disease. Yes, you would've thought they would have got some...
That sounds terribly like psychology to me. I annoyed one of my rheumatology colleagues over the years by refusing to allow my patients to be...
agree with Trish. This is completely wrong. Feeling awful matters in its own right. People with late stage rheumatoid arthritis are often very...
But the questionnaire is not designed to test 'the actual basis of fatigue'. It is designed to elicit the symptom the ordinary people call...
Interesting snippet. It isn't very well structured logically but the bits of data are interesting. The MHC includes complement genes and...
As I think Trish is intimating, this is not necessarily a question of degree of 'deconditioning'. Muscle change in ME might relate to a different...
Nobody doubts that, which is why it is used under carefully controlled conditions in trials. Actually, I am not sure it is that relevant here,...
Rheumatologists mostly use visual analogue scales for fatigue. And for drugs like TNF inhibitors and rituximab for diseases like RA you get slam...
Studies were done in the 1980s, many by close colleagues of mine - Richard Edwards, who was my chief at the time, Joan Round, David Jones and Di...
I thought you said we couldn't do that!! I think Andy was opening up a very important and complex discussion. But that gets back to the...
I don't think we have any evidence for controls being 'similarly deconditioned'. All we know for some studies is that controls were relatively...
You have obviously not been involved in much clinical research. Rheumatologists have been measuring fatigue for decades. It is not measured in...
I think the point is that there may be a variety of responses, and, as indicated above, some may relate to the symptoms PEM and others may not. A...
I have three thoughts about this. The idea of 'measuring PEM' is quite complicated. You might measure something that actually reflects symptoms -...
The peculiar thing is the statement 'our 3-month intervention seems appropriate'. It seems a waste of time. One might perhaps draw the conclusion...
“Clearly there’s got to be more, because one-tenth of lupus patients are men,” said David Karp, chief of the division of rheumatic diseases at the...
A very long post for those interested. It isn't quite like that. There is a divide between the general herd of immunologists who, since around...
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