That the effect shown in mice may have nothing whatever to do with the origin of autoimmunity in humans. If you play around with mouse genes...
That sounds like food intolerance which can either be traditional allergy or one of the more 'innate' responses like the common responses to...
Such as? As far as I know the only autoimmune disease with reasonably good evidence of T cell drive is AIRE. Type I diabetes might be but I have...
Because that is what the term was designed to mean. You don't suddenly say that 'horse' was originally designed to mean animals with hooves but...
The paper is a complete joke, using an irrelevant mouse model. Forget it. We know why women have more autoimmunity - because they have two X...
Yes, these things can in theory be measured objectively but maybe the problem is trying to devise an objective test for 'dysautonomia' rather than...
Or a third way - which might be both - which is that 'dysautonomia' is not a well thought out term. Whatever the tests are measuring it does not...
I have never heard that. Muscarinic receptor antibodies (and in fact all types of GPCR) occur in everyone and the general view is they don't mean...
"Depending on a patient’s presentation and testing, the treatment recommendations below are those used by ME/CFS clinical experts to treat various...
Oh really? So it's not so much that they don't work, more they were never intended to work? A complete con then? Well worth investing in.
But surely we should be very careful to deduce anything from that and it is no way a good reason for Bateman Horne to mention IVIg on a site about...
Thanks, I found it now on the site. Bateman Horne shouldn't be putting out a great list of unproven things like that - many of which have...
Most pain around joints and ligaments, and indeed fascia is non-inflammatory. It is just due to friction, pressure or tension stimulating...
I am not quite sure why we get stiffer with time. Some bits of us, like skin, tend to get looser, but joints mostly lose movement. What is...
Women are consistently more mobile than men. There are some bone profile differences involved - the female elbow bones allow more extension and...
Being very bendy or having lax ligaments had previously been called hypermobility or benign hypermobility syndrome. This too got a bit muddled...
Hi @Michelle, Let me try to answer some of those. Is 'EDSIII/hEDS' actually EDS? It took me ages to work this out clearly but I now have. The...
Hi @MountainRose We do not have any reliable evidence for a link between ME and immunodeficiency. In the past there was a vogue for calling it...
I agree. Also, I suppose that the relation in healthy people is a different matter from the relation between one in one disease and the other in...
The impact of TLR-7 malfunction is a very neat story. It may be worth noting, however, that it would make sense for this to be very specific to...
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