Furthermore, generalizability of the CD19-targeted CAR T cell approach to other autoimmune diseases is unclear. Again, yes, as we have said...
In the two patients with the longest follow-up, seroconversion of antinuclear antibodies was observed, indicating that abrogation of autoimmune B...
None of the traditional immunosuppressives mentioned have the sort of effect B cell depletion gives (i.e. as quoted in the above post). Belimumab...
Yes, we knew about that before we started with RA in 1998. Rituximab does not clear follicular B cells. But I am not clear that we have evidence...
Huge if it pans out. The findings so far are not really different from ours in 2000. The reported follow up of three months for some of the cases...
Almost all B cell based autoimmune diseases are more common in women. Differences in antibody production between males and females make sense...
Yes, it is exciting. But remember that Leandro, Edwards et al., in around 2000, reported a similar series (actually a bigger one) of SLE patients...
I am not sure how well your diagram illustrates the maths behind the problem intuitively, @Simon M. It is hard to think of a way to do it but what...
This is just wrong. Forget it. God knows how the publication system has come to the point where this is considered publishable. There is no...
I am afraid to say that I do not get that at all. Patients mostly grab on to ideas because they are oversold by researchers who have hyped weak...
I don't actually understand the justification for making meetings closed. I have never seen a need. The impression given is that the reason for...
Actually the situation is more complicated, @Pibee. The first trial in SLE was done by Maria Leandro and myself and it was clear that major...
Not putting out completely baseless and meaningless diagrams might be good too. This is why it is so important that we are as. critical of the...
I am unclear what it would mean for SNPs to be significantly associated with 91% of a population. I would expect a statistical association with...
It is pseudo medicine. It is a pity that MERUK are treating it as plausible. You don't develop tests in this way. Long Covid is a clinical...
Dr Topol seems easily pleased. The review seems to meander through everything and come to no very useful conclusion. There is a marked absence of...
It sounds as if they have identified some of the signalling characteristics of neutrons involved in feeling ill following endotoxin (as in typhoid...
Is there any reason to think that the German government is delaying, though? @RedFox My understanding was that Berlin Cures had withdrawn their...
This looks like a serious muddle. Why should normal process be bypassed for a treatment that so far has little credibility and no evidence of...
There is a deeper problem with this approach. The gold standard for machine learning is the existing clinical diagnosis. If all the test does is...
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