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In the graph above the greater variance in ME/CFS could be due to the decline in strength over the 10 repetitions. If I take only the first 3 repetitions, the variation between groups looks similar.

Was looking at one of the reference in the paper, a review Shechtman 2000 which was highly critical rather than supportive of the measure. It also points out what seems to be the issue here: So I think that's whats happening here: the standard deviations between patients and controls are...

Had a closer look at the raw data, available here: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02774-w EDIT: posted some other graphs earlier but these were incorrect (they focused on the variation per group rather than per individual). Below is a graph of the...

The difference seems quite large. So apart from the authors interpretation what would be the most likely explanation for this? Is it simply that being ill/having lots of symptoms causes the variation in handgrip strength measurements?

Seems like there is an inflation of the term autonomic dysfunction or dysautonomia. In this paper they report that "38% of the healthy controls had autonomic abnormalities". If it is so common, it's probably not an abnormality anymore? Using the lean test (not tilt table) the study found that...

Probably this study by Peter Novak: https://www.nature.com/articles/s41598-024-52368-x

Not sure if the term 'autonomic symptoms' is a useful category. For at least some of the symptoms it seems that the problem could lie elsewhere than in the autonomic nervous system?

I don't think there's a paradox here. It just shows that the author probably doesn't know anyone with ME/CFS and how a life with severe ME/CFS looks like. Talking to patients and getting to know their life (as Jo has done here and on Phoenix Rising) would help doctors to understand the illness...

They seem to say that they found something similar to the preload failure of Systrom's group: The novel aspect of the paper seems to be that they used O2 pathway analysis, which tries to break down oxygen transport into different aspects. In ME/CFS and Long Covid patients, the problem seems to...

In the DecodeME sample, they did quite some efforts with the questionnaires + self-reported clinical diagnosis to ensure patients had ME/CFS. So I don't think its likely that misdiagnosis would affect the results so much to create spurious relationships of this magnitude. Another option is that...

Social media summary: 1) A new paper found a slight increase of Fibroblast growth factor 21 (FGF-21) in ME/CFS patients compared to controls. FGF-21 is a hormone-like protein that helps to regulate metabolism and has been found to be increased in previous ME/CFS studies. 2) Below is the data...

The intercept of LDSC is often used as a measure of stratification effects or confounding bias. It should be close to 1. If it is substantially higher, it would suggest that population differences between group are inflating the p-values. The good news is that this isn't the case in DecodeME...

With the help of @forestglip, I've finally managed to run linkage disequilibrium score regression (LDSC) on the DecodeME results. The original package is written in the outdated Python 2 which caused all sorts of errors. So I've used the Python package GWASlab which provides a wrapper function...

Social media summary: 1) 7 new ME/CFS projects have received funding from the Dutch research agency ZonMw. All projects look high-quality and focus on different aspects such as the brain, muscle, microbiome, viruses, orthostatic intolerance, and the immune system. A brief overview 2) The...

7 new ME/CFS projects have received funding from the Dutch research agency ZonMw.All projects look high-quality and focus on different aspects such as the brain, muscle, microbiome, viruses, orthostatic intolerance, and the immune system...

I also think that the UK Biobank has a lot of these depression and anxiety related categories and less for autoimmune or mitochondrial disorders. There also seems to be a difference between the 0.7-0.75 correlation for CFS and IBS and the 0.5-0.55 for the depression categories. But in all, it...

Thanks, makes more sense to do a bonferroni correction, the results are largely the same. I assumed that those with an rg value of 9999 are unvalid, so after excluding those I got 3167 remaining tests. So the bonferroni p_value is the p value times 3167. I will update the results above.

I suspect you filtered on the lowest p-values? One issue is that this may be affected by the sample size of the trait rather than the strength of correlation with ME/CFS. Because we also want to avoid having lots of false positives, I tested an arbitrary threshold of p < 0.00005 and then ranked...

The DecodeME questionnaire asked about 'Clinical depression' as one of the other conditions participants might have. It would be interesting to see if the answer to this question determines the similarity to the depression GWAS. In other words, if we see similar results in ME/CFS patients, if...

Thanks, I suspect this will be one of the areas where the preprint may need to adjust the wording a bit. There does seem to be a link/similarity to depression based on genetic data. That seems like a confirmation of the data that this came out on top in the UK Biobank. That's a bit surprising...