Search results

Are these tests actually legit? I never know whether they're just pure pseudoscience or not.

Yes, they've taken the ICC PENE critera (5 items) and just completely butchered them so that they become about 'tiredness'. Just bizzare. Why take the most strict/restrictive diagnostic criteria and then water them down? :confused:

Yes, I suppose you could look at it that way. I could have just written the first paragraph about the anomalously high prevalence rate in controls and then stopped! That probably would have been better!

I think this is clickbait. It's a grandiose statement going against conventional wisdom (that long covid is associated with ME/CFS) despite being based on an extremely low powered observational study.

I assumed the scoring system was their own invention. It's certainly nothing to do with the ICC. Now wondering if it's based on De Paul. If it is, they've not mentioned or even referened it at all.

I have left a comment. I don't have the energy to spend a long time on this, but I think I covered some of the main criticisms here. -- The authors report an ME/CFS prevalence rate of 10.8% in their control group. This is 10–20 times larger than the best estimates of the prevalence rate from...

It really seems to be a big problem now, made much worse by poor long covid research.

Will be interesting to see if this gets published. I have no doubt given scientific publishing and peer review standards that they'll find a home for it.

I don't even know where you'd start with this crap. Probably a lost cause.

It's not significant if your error bars are longer than a giraffe's neck.

This must be the most bizzare abstract I've read for many, many years.

Interesting links between chronic stress, depression, and autophagy, bringing in mOTR and the anti-depressive effects of rapamycin.

Chronic stress remodels brain homeostasis, in which persistent change leads to depressive disorders. As a key modulator of brain homeostasis, it remains elusive whether and how brain autophagy is engaged in stress dynamics. Here we discover that acute stress activates, whereas chronic stress...

I'm afraid I'm skeptical of this story. Urine thyroid tests don't seem to be used at all, and are in fact recommended against, whereas blood thyroid tests are and have been for decades. Here's a paper in Dutch that concludes that 24-h urine tests for T3 and T4 are not accurate and cannot be used...

This paper suggests that bisoprolol has similar efficacy as propranolol for PoTS: https://www.neurotherapeuticsjournal.org/article/S1878-7479(23)01061-9/fulltext (I realise not all OI is PoTS.)

There's reasonably good evidence that propranolol improves symptoms of POTS, e.g., https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.108.846501, but I'm not sure its fully understood why. One theory is that excessive heart rates don't allow the heart to fill properly and so cardiac output...

What is the stats/maths behind this statement, please, i.e., where does the 150 come from?

Alan seems a touch angry, but I have to say, unless I am missing something, I am not really seeing the significance of this particular paper and its results, except for the fact some results have been replicated.

I think that's the whole point.

I have one reading, from a medical I had at the University of Leeds in 2014, before extended fieldwork. The value was 214 iu/L, which wasn't flagged because the stated normal range was given as 70–300 iu/L, but looking now this range seems wrong for an adult and my result is actually high.