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Yeah i vividly remember all the muscle i built from couch to 5k just melting away once i deteriorated.

I forsee this ending poorly...

Ah maybe it is just the political inconvenience of acknowledging it in kids.

Just like when they pretended kids weren't getting really sick with acute covid.

They are the ones that need behavioural support.

I strongly suspect they will be advising it's psychological in adults too.

I wonder where they are getting their advice from? Surely not a certain jolly prof who's chummy with this Labour faction? Whoever it's coming from they are harming kids to an almost unthinkable degree. All because it's politically convient to forget covid. Never forget the widely publicised...

I'm hoping the inclusion of 9000 LC patients in SequenceME will help the two spheres coalesce somewhat. Although thats a couple years off and not funded yet as far as we know.

Agreed.

Institutionalised exercise induced deterioration for long covid suffering med students. What a mad world we live in.

No worries, I believe so. I found these two links from a quick google. I think there is more info on S4ME but I am brain fogged right now! https://www.omf.ngo/pediatrics-me-cfs-deep-omics-profiling-and-longitudinal-study/ https://www.omf.ngo/omf-scientist-receives-grant-in-australia/ Edit...

This is very needed but I trust BACME about as far as I can throw them.

This makes intuitive sense to me but that is probably meaningless. Two thoughts and you've probably already had both of them but just in case you havent: Chris Armstrong's team are/were doing a study that involved sampling people in active PEM with home visits iirc, so he might be a good...

Type 1 interferons again!

Does anyone know if Hanson's group are replicating this paper in a larger cohort? it seems really interesting and I would really like to know if it stands up. Especially after PRDX6, which is higher 15 mins after exercise here, popped up in DecodeME.

That's interesting. I don't know very much about the biology of exercise but I think I follow just about! Does anyone know if Hanson's group are replicating that paper in a larger cohort?

Very interesting! How would we test the hypothesis that type I interferons are involved in ME/CFS?

I feel like this paragraph definitely puts the dampener on things: Lots of people who have had covid have some kind of persistent markers of infection in their blood and no long covid samples. So it stands to reason these post exercise markers could be a similar phenomenon. Also they gave...

Downregulated in LC here: Strangely higher 15 mins after exercise in this small Hanson study:

Well now I want to read his sci-fi novel!