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No it's probably me! I felt like I could almost grasp it the second time I read it

It's probably a mark of how bad my brain fog is today that I can't tell if this post is a joke :dead:

Completely agreed.

Well, that's very disappointing but not at all surprising. I guess the hope for UK research funding lies solely with the Edinburgh/AfME initiatives. Obviously I want treatments as fast as humanly possible, but in the meantime I would really love it if I could be treated like what I am - a...

Surely it is possible that there is one mechanism for the fatiguability and another one for PEM, and that they show up together in ME/CFS because the capillary thickening is caused by a process downstream of the one that triggers PEM? On the other hand, weren't these biopsies taken from mild...

How can anyone delude themselves this way let alone trained medical professionals? It never ceases to alarm me.

What does this even mean? We don't know the root cause of ME/CFS. This is exactly what I'm talking about, the viral persistence lot seem to have an assumption of cause that preceeds or superceeds the need for evidence.

I have to say I feel pretty skeptical about anti sars cov2 monoclonals as a long covid treatment. I just haven't seen much compelling evidence that viral persistance is a driver of symptoms. And all the antiviral drugs that have been tried so far have had no efficacy.

I have always gotten a runny nose, sneezing and sometimes coughing fits when I am having the kind of PEM that feels seriously viral. It happens far too often to be explained by catching colds. It is part of the reason I thought my immune system had been weakened by my triggering strep infection...

There has been no word on Recover TLC for a while. It would be good to know what drugs they are planning to try although not holding my breath after the drug choices for the first round of trials.

If only that was a barrier to success for them...

Ah so I knew the Fukada critera weren't great but don't know much about them as a researcher.

I didn't know this. Was it by BPS clinicians? That might explain the use of the term 'malaise' which imo is not that much more helpful than 'fatigue'

Some quotes about the work following on from this

Will there be a way for severe patients to participate?

Made a similar calculation and came to the same conclusion

So do you think there's a chance it could work then? Setting aside the unclear hypothesis/reasoning?

I have just googled this peptide and seen it is considered an exercise mimetic. Isn't there a possibility it could mimic the biological processes of exercise that trigger PEM, since we don't know what they are yet?

'This work matters to patients because it suggests that treatments that help immature B cells use energy efficiently and survive immunological attacks may help people with ME/CFS.' What treatments do this? Fluge and Mella and Schibenbogen are pursuing B Cell depleting drugs, which don't sound...

I've discussed this elsewhere but I think I had a prodromal phase of about 6 years. Although sometimes I think about certain details, like the fact my hangovers tended to get nastiest almost exactly 12 hours from my last drink rather than as soon as I woke up, and how much sicker I tended to...