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Very cool. Can you tell that I - although a fan of IGeneX - have never used any of its products? I like that they test for more than one strain, and for several species. As I recall, the NIH used to refuse to test for anything other than Bb sensu stricto. This made no sense to me - how do you...

I had the vague feeling immunoblot and western blot were pretty much the same thing, or at least employed the same process. I could be wrong. IGeneX, as usual, simply allows for more bands than conventional testing, including OspC and OspA. Unfortunately, dx will remain questionable despite...

https://igenex.com/press-release/lyme-immunoblot-receives-fda-clearance/

Viruses are pretty much everywhere, of course. Still, this nematode study is curious, if only for potential import. https://www.lstmed.ac.uk/news-events/news/newly-discovered-viruses-in-parasitic-nematodes-could-change-our-understanding-of

Personally, I'd like to see something that reflects the individual nature the disease can manifest itself in patients. (awkward wording, sorry) Something that captures that ME/CFS is characterized by a symptom complex or amalgam. I'd emphasize those symptoms can vary by individual in frequency...

Add bartonella (have a cat?) and babesiosis (take walks in parks or woods?) to that list, at least potentially.

Diseases, and particularly infections, that attack red blood cells are, I think, more common than most people appreciate. Since impaired skeletal muscle function is at play in many such cases, perhaps there is a subset of pwME that may be impacted.

Thanks for the explanation. I thought it might be something along those lines when I read the discussion. Still seemed needlessly psychological when trying to infer organic brain problems. It warrants a slower and more deliberate read-through, if only for the historical Wallit ties.

This "cognitive conflict" reference is unsettling.

@Dakota15 , your effort and attention to detail, and time to register it all here typed in word by word, is breathtaking.

As far as I could ever tell, Marques was loyal to the CDC diagnostic formula, including for spinal fluid. Even so, she would have had plenty of qualified recruits. This idea that chronic Lyme cannot fit into the CDC/IDSA diagnostic paradigm is just a myth. Oddly, Marques knows that, I think...

So evidently Nath felt similarly to me about what he should have been able to draw from the NIH Lyme study.

Right. So she had people who crossed all those hurdles. Remember, we're talking over 15 years of recruiting. a) Igenex sells some good tests. They test for more strains than just B31, and allow 2 proteins/bands, particularly relevant to late stage Lyme, that CDC testing removed due to vaccine...

Maybe. It shouldn't matter. I'd still imagine she'd have been able to pull together a decent cohort. Certainly at least one. Nath sounded bitter to me.

Sorry, but that is incorrect - at least relative to Marques' chronic Lyme/PTLDS study participants. Each had to satisfy strict IDSA/CDC diagnostic criteria before qualifying to even meet with a Marques underling. This is pedigree Lyme shit we're talking - with the population accruing since 1999...

"Adriana Marques (chief of NIAID's Lyme Disease Studies Unit) was supposed to produce all these patients with post-Lyme. She didn’t produce one patient. Not one” To my tin ear, Nath sounds a little resentful here. I could be wrong. Still, a simple follow-up question I'd have wanted to hear...

During Q & A, Nath responds to a question about studying more than one disease at a time. I am tired, but it seemed to me he suggested that early on in the ME/CFS study design his group was going to look at ME/CFS and post treatment Lyme at the same time, and that the NIH's Lyme head couldn't...

Can't help but wonder if antigenic variation might play some role. Also caught my attention that malaria causes this IgM to IgG mishap. I wonder if other parasites might do the same (e.g. Babesiosis), as well as other pathogens. Great conference, with a curious and good assortment of speakers...

So there's this: "Considering the type of symptoms observed in CLD that share the common features of exacerbated central nervous system pain and sensory-processing mechanisms, CLD is included within the group of pathologies associated with central sensitivity syndrome (CSS)24. Pro-inflammatory...

"Transitioning into a long-term project will teach us so much that we need to learn about the post-infectious complications for Covid, and ME/CFS, chronic Lyme disease, all of these chronic conditions" I suspect there are people at the NIH that are apoplectic that she said "chronic Lyme...