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Yes. Agreed. But it's complicated by issues you don't necessarily see in ME/CFS (just as ME is beset by things you don't see in Lymeworld). One example is diagnostics. Let's say you dedicate all that $25 million to erecting a diagnostics' platform that actually identifies directly whether you...

I'm all for getting more money in an area that is seriously underfunded, and I applaud such efforts, especially successful ones. That being said, depending where that money goes, it could be little more than Groundhog Day.

Broadly speaking, yes, and - on paper at least - for longer. These (TBDs and ME/CFS) are in large part diseases whose narrative is politically derived and maintained

Allocating more money in theory is a positive. Respectfully, throwing that increase at more or less the same groups who have failed patients for almost a half a century doesn't strike me as "a pretty big deal" anywhere. If a few million more $'s were allocated for ME research and given to the...

Meh. $25 million for "Lyme", defined and characterized by whom, spearheaded by whom? Spent by whom? As for $125 for tick-borne diseases, sounds alright until you realize how many TBD's there are - and how prevalent some have become. Babesiosis alone could use that amount. I suppose it...

To me, this simply seems poorly worded and vague. First, pwME can suffer from OI even when not in PEM. Perhaps if they had observed that PEM exacerbates OI symptoms, it may have been closer to the mark. Second, they appear to be equating energy expenditure with PEM triggers. Maybe so, but...

Spite?

You have to know where to look, and what you're looking for.

Back in the early 1950's the Nobel Prize went to a couple of guys who demonstrated that a fetus can inherit from its mother an immunological unresponsiveness toward an antigen or group of antigens. But some veterinarians had been purportedly toying with the concept before that, and well after...

If immune tolerance is at play, odds are nothing would.

Could still be a downstream effect of a virus, just not a flare per se. Acquired channelopathies come to mind (just as an example).

I'm pretty sure we discussed it here. Sorry, my brain can't work the Search function.

It could be a lot of things. My vague recollection is he found NO evidence of ANY pathogen - virus, bacteria, or parasite - in ANY OF HIS COHORT (if I recall correctly, and I may not be). Given that his cohort was in large part from the NY metro (if I recall correctly), that would be quite...

I believe this may apply to me as well. Not clear if it's viral, though. Overall though, in terms of persistence, the more I dig into immune tolerance and it's role in viral reactivation, the more I suspect it may prove relevant.

I recall it well. I was not impressed then either.

If the diagnostic is questionable - and far too many actually are - its significance would be limited. This also holds true for reactivation metrics.

I'm not sure how meaningful this is. Put another way, this is about as meaningful as claiming there is pretty good negative evidence for persistence of Borrelia, Babesia, or Bartonella in ME/CFS - which is not very meaningful.

Thank you, @Hutan. Although the study technically concerns Lyme, it's the scanning technique, and the purported brain inflammation it suggests, that drew my attention. The Johns Hopkins press release seems to focus on that more than Lyme as well, although that is debatable...

The suggested neuroinflammation was what I found intriguing - and how that could translate in ME/CFS TSPO imaging efforts (reminiscent of Nakatomi et al). It sure feels like neuro-inflammation is at play. I noticed the study indicated that neurocognitive exams on the cohort of 12 demonstrated...

Another PET TSPO neuroimaging study suggesting neuroinflammation involving microglia, this time in PTLDS: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1381-4