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    VEGF - Vascular Endothelial Growth Factor

    @Hutan , that was very nice of you. I think Vegf may be relevant as a marker because of the cognitive decline many of us experience. So I think in many of us we will show low Vegf, which is fairly remarkable. It also would explain the hypoxia and low body temps (i'm often less than 97F). If we...
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    Post-COVID-19 syndrome: retinal microcirculation as a potential marker for chronic fatigue, 2022, Schlick et al

    Sorry. I'm tired. This link is worrisome to me. I'm probably wrong. But who of us has tested our serum VEGF? I have over several years, off and on. What cursory searching I've found is that often it doesn't have a good outcome, at least with cognitive stuff. I test weird so of course I wonder...
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    Post-COVID-19 syndrome: retinal microcirculation as a potential marker for chronic fatigue, 2022, Schlick et al

    Again, I am brought back to VEGF. Wish they were talking cognitive decline....
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    Endothelial dysfunction in ME/CFS patients, 2023, Sandvik, Mella, Fluge et al

    Any one care to take a stab at figuring how low VEGF might play into this?
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    Ingestible Sensor Could Help Diagnose Gastrointestinal Motility Disorders

    If it's removed through one's navel with a weird thingee, count me out. Neo, run!
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    PEM without heart rate change?

    But God spare us from the hubris of US cardiologists. ;)
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    What to expect from infectious disease testing?

    Acute Lyme? I'm just curious.
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    What to expect from infectious disease testing?

    Of course, Lyme would be the exception if you accept what most infectious disease doctors embrace. Not only that, but in most cases one's Lyme antibodies should be IgG positive (since it usually takes longer than 30 days to get tested, at least historically). Interestingly, another exception...
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    What to expect from infectious disease testing?

    I do. Conventional wisdom is that it's possible that you may always test positive - but that's just a theory. Conventional wisdom also says if you do test positive, your titres should decline. If you have multiple tests, and your titres decline then rise then decline then rise etc, that's...
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    Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition,2023, Siwen Wang, MD et al

    Conclusion: I'm thinking maybe a tad judgmental and highly doubtful. Relevance: Perhaps to several characters from The Donna Reed Show?
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    Central Sensitization and Chronic Pain Personality Profile: Is There New Evidence? A Case-Control Study 2023 Lopez-Ruiz et al

    I'm not sure the authors are clear on what is meant by personality traits. In particular, if someone is in pain, and he tries to avoid doing things that exacerbate the pain, that avoidance does not qualify as a personality trait. It qualifies as a subset of common sense.
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    Prognostic factors for persistent fatigue after COVID-19: a prospective matched cohort study in primary care 2023, Konig et al

    Also, high education level, multiple partners, fans of Ann Rice, stubborn people, men who are fond of bow ties, woman who are fond of bow ties, low frequency of GP contact, people who enlist in the armed services, draft dodgers, and everyone from the US state of New Jersey.
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    Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 Variants of Concern induce neuroinflammation... 2023 Erickson et al

    Covid crosses the BBB. Then what? Does it have a tropism for different parts of the brain? Is it indiscriminate as it ravages like 9th century Goths? Do symptoms mirror neurosyphilis or neurolyme? What time frames are involved? What happens in 6 months? 6 Years? Ive read atrophies of grey...
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    No Causal Effects Detected in COVID-19 and ME/CFS: A Two Sample Mendelian Randomization Study 2023 Xu et al

    Sounds to me like they're clueless and they elected to punt. Persistent muscle soreness? Interesting that they characterize Covid as an infection and not so ME/CFS. They do seem to reduce ME/CFS to pain with fatigue, so, you know, clueless. Give the ball to someone else.
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    Long-term high-dose immunoglobulin successfully treats LC patients with pulmonary, neurologic, and cardiologic symptoms, 2023, John S Thompson et al

    What are case reports if not a trial run for a clinical trial? Besides, I am a bit familiar with this sort of NIH group think. Three months is like code for long-term. If this were an abx treatment RCT, three months is a lock for whatever result they want.
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    (CDC) Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2023

    CDC really is more advertising agency than medical research entity, right? The NIH is the research arm, or at least what passes as research.
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    USA: NIH National Institutes of Health news - latest ME/CFS webinar 14 Jan 2025

    I think I will apply for their research roadmap working group. Hope my name doesn't throw up any red flags. It might. I've some history there. :)
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    Long-term high-dose immunoglobulin successfully treats LC patients with pulmonary, neurologic, and cardiologic symptoms, 2023, John S Thompson et al

    Six patients for three months. Six. For how long again? Three months? In what fantasy world is three months "long term"? I think of long term from the patients' perspective, which means years. I'm not sure three years qualifies as long term. Maybe. Thirty does; thirty would qualify. Three...
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