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I’m sorting an audio version, a few pronunciation questions… “FcγRI” I’m going for “Fc gamma R one” “α1β4 integrin traffic domain”, “Alpha one beta four integrin traffic domain”? “MAIT cells are pronounced “mate” aren’t they? I think most of the others are initialised, things like GDF15, TNF...

That jumped out at me too, my understanding is this is a real thing, or rather the application of quantum mechanics to biology is. But like so much of the world of woo, people have taken it and re or misappropriated language and ideas and... *sigh*

They’re probably confused at all these hits to their archive page… refreshing looking for new papers. At least we know someone has found the admin password and they’re up and running again!

Putting the p value in parsnips?

Nice work @Sasha :thumbup: I’m just doing names for now.. how about Interferon Mediated T-cell Involved Resource Exhausting Disease Yes, I’m Tired

Complex pathways you say… Image source and more information here. Or slightly less scarily ‘what is an interferon?’

Excellent thank you. I can cope with probabilities, greys rather than black and whites. Combinations of complex interactions shifting this or that way. It seems to be how so much in the world works. You’ve often talked about this idea so it makes sense to have it explored more...

Milligan’s Disease as in ‘I told you I was ill” (Ford) "you'd better be prepared for the jump into hyperspace. It's unpleasantly like being drunk." (Arthur) "What's so unpleasant about being drunk?" (Ford) "Ask a glass of water."

Or for more fun maybe we can find something that works for Gimlet or Gimli?

Gamma Receptor, Interferon Mediated, Nociceptor Exciting, Serious Syndrome

There does seem to be a good gap in the publishing archive since last Monday (with just one slipping in on Tuesday). Maybe everyone in the office took the week off? https://www.qeios.com/archive?type=article

Oh well in that case more questions! 1) How would this all fit in with Ryback et al’s findings of increased IGHV3-30 and skewing in the ratio of IgM to IgG BCRs seen in mild/moderate people and not in severe? 2) The basic mechanism seems to be of different cells all doing largely what we’d...

It’s well known that pasties cure all and my hypothalamus definitely has a clock which measures how long since I’ve had one. Or maybe it’s just the swede…

My first thought was that this could explain why I don’t know my antigen from my elbow… But maybe a nerve needs to know about localised things for other reasons. Perhaps its just a hangover that lots of cells have from earlier cell evolution. Or could it be that it’s useful for a nerve to know...

They only mention ME/CFS in passing in their abstract and conclusion, with the main focus being on fatigue and chronic fatigue.

Intelligent Eye Tracker Integrated with Cylindrical Capacitive Sensors for Chronic Fatigue Assessment Tianyi Li, Seo-Hyun Park, Changwoo Lee, Shawn Kim, Younghoon Kwon, Hojun Kim, Jae-Hyun Chung Abstract Fatigue negatively impacts health, safety, and productivity, yet current monitoring...

Genecards shows this for expression of FCGR1A https://www.genecards.org/cgi-bin/carddisp.pl?gene=FCGR1A#expression Maybe someone who has a better grip of this can get something useful from the expression atlas? https://www.ebi.ac.uk/gxa/home

Woohoo! Sunday has been a success. Thanks Jonathan and thank you to the greek gods of qeios for the extra time to digest information. This is all sounding very intriguing…

A couple more useful bits, I don’t seem to be able to edit my earlier post to add them now but… Bite Sized Immunology Phagocytosis https://www.immunology.org/public-information/bitesized-immunology/systems-processes/phagocytosis Complement System...

If you’ve been through the immunology basics and know what a phagocyte is but want to understand more about some of the processes they and other cells use are here are some resources. If you don’t know what a phagocyte is start here or check out the thread on Learning about the immune system...