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I found this interesting in general and thought others would. A scientific development with potentially relevant applications and also ties in with recent discussion of usefulness of AI/ML. I also think it’s an area @Jonathan Edwards is very familiar with!

Microsoft AI Research has made a tool called Skala available for everyone to use. It was previously an internal research project. Here’s the new Azure Skala page. What is this all about? There’s some info this webpage about the DFT research project Most accessible is probably this blogpost...

Great work @Joan Crawford and thank you, am sharing where I can to try and get some eyes and donations to help your efforts

Agree that focussing on predefined activities is the wrong path. Different people of different severities with different levels of support prioritise different things. This just isn’t an accessible questionnaire, in size or structure. I gave up on it. I believe there will be self selection in...

Oh yeah… I’d missed that! Thanks both for the explanation. Thanks for the insight. Useful to know.

If you did want to Khan Academy has a couple of good modules This AP Biology one And this MCAT module

Or they’ve got a good PR team? I was surprised to hear about it first from the media rather than here tbh.

Yeah, I think some of as are roughly saying the same thing. Maybe with some differences in how we dress it up. Others seem to think it’s not worth pursuing at all. It seems clear from the factors raised by Chris Ponting and Kevin McConway that this shouldn’t be being reported as a test with the...

The section on diagnostic value has some interesting bits too. I don’t think they’re completely ignoring the limitations here and they do call this a proof-of-concept study And on use of their technology Here are links to the papers referenced in this section for people who want to read...

This on CD4 from the pathway analysis HLA-DRA also popped up in Fig 4 although I’m not sure of the significance. Some quotes on the potential for specific subgroups And

Why? In my mind seeing if they can reproduce the results, albeit while resolving the concerns raised, is exactly what we need.

There’s definitely lots of the usual narrative of inflammation, neuro-inflammation, dysregulated immune states, etc. It has the feel of one of those papers which is trying too hard in parts and perhaps doesn’t try hard enough in others leaving me questioning the findings the more I read...

Thanks. Really useful to have your thoughts and look forward to others too. There seems to be a lot of the usual framing throughout but wondered if there may be something there nevertheless. But am having difficulty getting my head around it all and am not sure if that is the paper, the...

Understood. My question is still if this can be replicated will it tell us something useful about what is going on? It seems so from the pathways section of the paper? If you’re also not comfortable being drawn on that sort of speculation I get it. It just seems pretty relevant here as there...

I agree. But if this does turn out to be accurate it potentially does tell us something doesn’t it? At least that’s what the pathways section of the paper seems to indicate? And why I asked Chris about it, although completely understand his response you can’t blame me for trying :) Of course it...

Understood. Thanks @Chris Ponting @DMissa I’m not sure it is, the tweet says But I cannot see this claim in the paper and the criteria for the UK ME/CFS Biobank are stated as We have in the past trusted the Biobank sampling. The other concerns @Chris Ponting raises seem more relevant

Thanks for this @Chris Ponting I was just about to share your comments. Looks some we need some caution then. Would be great if we could see this replicated of course. Did you have any thoughts on the signalling pathways they identified and if this fits in with DecodeME at all?

Precision Life have the data and are into the idea of subgroups. Difficult for us to interpret given their analysis methods are a black box and they don’t seem great at communicating with us. But if they show some subgroups with the same data and can explain and perhaps tie it to the same...

Wow, formal language and management speak but brutal. My interpretation: Leadership and role clarity - There is no leadership and there are conflicts of interest Governance structures - The processes in place to do the basics any governance structure should are not present Member engagement -...

Sorry I haven’t caught up with the whole discussion but have been through the overview and wanted to thank @PeterW for the obvious work, time and effort spent on this. Thank you. You’d make a good trustee!