Feasibility and tolerability of dual-target repetitive transcranial magnetic stimulation (rTMS) for treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): An open label pilot study
Juliana Corlier, Hrag Peltekian, Thomas E. Valles, Cole D. Matthews, Doan Ngo, Reza...
Part of the discussion was about how the difference might have been driven by contraceptive use:
I think it would have made sense to consider contraceptive use in this paper as well, but I don't see that word mentioned.
Linking to the thread for a fibromyalgia GWAS since there was a signal in the same region and they believe it may be related to GPR52:
The two relevant loci in DecodeME, showing that there may be a signal in the HTT region in ME/CFS as well (black triangles are locations of top hits from...
More from the paper:
As the images I posted above show, there seem to be at least suggestive signals (p<5e-6) at these same two locations in DecodeME. So maybe GPR52 and HTT form an important pathway in ME/CFS as well.
Another drug target:
The gut microbial composition is different in chronic fatigue syndrome than in healthy controls
Monika Prylińska-Jaśkowiak, Hanna Tabisz, Sławomir Kujawski, Beata R. Godlewska, Joanna Słomko, Beata Januszko-Giergielewicz, Modra Murovska, Karl J. Morten, Łukasz Sokołowski & Paweł Zalewski
[Line...
Fibromyalgia and hand diseases: A case-control study
Eli Magen, Suhail Aamar, Viktor Feldman, Israel Magen, Eugene Merzona, Ariel Israel
[Line breaks added[
Highlights
• FM triples risk of carpal tunnel, De Quervain’s, and trigger finger.
• FM linked to higher rates of carpal tunnel release...
Endometriosis and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis
Sabrina Compton, Rodolf Alkabalan, Judd Cadet, Azin Mastali, Prakash V. A. K. Ramdass
Background/Objectives
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and endometriosis...
Now published:
Gulf War Illness, Fibromyalgia, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID Overlap in Common Symptoms and Underlying Biological Mechanisms: Implications for Future Therapeutic Strategies
David Mantle, Joan Carles Domingo, Beatrice Alexandra Golomb, Jesús...
Now published, see post #6
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Relationships Between Fatigue, Cognitive Function, and Upright Activity in a Randomized Trial of Oxaloacetate for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Suzanne D Vernon, Candace Rond, Yifei Sun, Shad Roundy, Jennifer...
Anti-neuronal and anti-mitochondrial autoantibodies are associated with lower functional status and more severe respiratory symptoms in post COVID syndrome
Antje Vogelgesang, Anke Steinmetz, Angela Stufano, Valentina Schino, Domenico Plantone, Agnes Flöel, Guglielmo Lucchese
[Line breaks...
I pulled up the top hits from this study and compared to DecodeME to look for those that are in the same general location as at least a somewhat significant locus in ME/CFS.
So these images are the results for ME/CFS, but with the top fibromyalgia SNPs marked as black triangles and with their...
I don't know if it's circular. It's more like NK cells might be relevant because of the study correlation. And ADCC might be relevant if NK cells are relevant. True, there might be other possibilities for why NK cells were significant (including randomness).
If we suppose that high NK count is related to better antibody dependent cell cytotoxicity, might the fact that the correlation was with blood NK cells provide a clue about where the cells that need to be killed are?
The multiple myeloma studies found correlations with NK cells in the bone...
Well nothing indicated that people with high NK cells had worse ME/CFS. There's the possibility that NK count doesn't have much to do with the illness itself, it's just if you happen to be a person with high numbers, dara can work more effectively.
An imaginary related example is if there was...
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