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Defining a long COVID ‘expotype’ within the P4O2 COVID-19 study J.C.S. Holtjer, L. Houweling, L.D. Bloemsma, M.E.B. Cornelissen, A.H. Maitland-Van der Zee, L. Portengen, S. Kakhaia, R.C.H. Vermeulen, G.S. Downward, the P4O2 consortium [Line breaks added] Highlights • First study to...

Now published: Global Prevalence of Long COVID, Its Subtypes, and Risk Factors: An Updated Systematic Review and Meta-analysis Yiren Hou, Tian Gu, Zhouchi Ni, Xu Shi, Megan L Ranney, Bhramar Mukherjee [Line breaks added] Background This mega-systematic review evaluated the global prevalence...

Uncorrected proof published on PLOS Medicine: Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia [Line breaks added] Background Preventing and treating post-acute sequelae of SARS-CoV-2 infection...

The following newly released thesis looks like it might be the same study, though the details aren't exactly the same. Thesis Identifying the Neurobiological Substrates of Gulf War Illness, 2025, Jones

I think this might be the same study as the trial registration in this thread, though the details look a little different. Assessing Neuroinflammation in Gulf War Illness Using Magnetic Resonance Spectroscopy, Younger

Identifying the Neurobiological Substrates of Gulf War Illness by Chloe Jones Jarred Younger, Committee Chair; Adam Goodman; Maxine Krengel; Virendra Mishra; Robert Sorge [Line breaks added] Abstract Gulf War Illness (GWI) affects approximately 30% of veterans who served in the 1991 Persian...

Studies from the first few pages of results on Google Scholar (and one found as a citation) related to NKT cells in people with ME/CFS: - Abnormal T-Cell Activation And Cytotoxic T-Cell Frequency Discriminates Symptom Severity In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025...

It's just assumed that participants in an unblinded trial filling out a questionnaire differently means their symptoms improved. No mention of the possibility of bias related to subjective outcomes in the limitations.

It looks like you can download summary stats on the GWAS Atlas website. I'm not sure if it has data from exactly the same study you linked, but it has several for depression. For example, there's a depression trait which looks like it has NEGR1 as significant. Clicking the link next to "File"...

Multiple Sclerosis Rheumatoid Arthritis

Some posts about a previously planned GWAS in the USA were moved to: USA: Center for Solutions for ME/CFS - news and updates from Columbia University's NIH funded center, Lipkin

From the first study: Ultra-rare variant in CACNA1B found in two siblings with PANS, and the same variant was previously found in a woman with ME/CFS+anorexia. Edit: And I don't know how related CACNA1B and CACNA1E are, but the latter was the closest gene to the 23rd most significant locus...

I don't think I've seen all the discussions, but I've seen you refer to psychiatric disorders as disorders of "thought" or something along those lines. Relating to "thoughts" and "mind" is barely a concrete category in my opinion. Anxiety to me feels like the mental version of physical pain -...

"Psychiatric" feels to me like an almost useless term. The difference between obsessing about a specific thought (OCD), having little motivation (some forms of depression), yoyoing between high and low mood (bipolar disorder), and seeing things that are not there (schizophrenia) seem about as...

Some discussion has been moved to the following thread: Heathrow incident 8/9/25 claimed to be mass psychogenic illness

Acute Effects of Osteopathic Treatment in Long COVID-19 Patients with Fatigue Symptoms: A Randomized, Controlled Trial Ulrich M. Zissler, Tino Poehlmann, Rainer Gloeckl, Sami Ibrahim, Kerstin Klupsch, Tessa Schneeberger, Inga Jarosch, Andreas Rembert Koczulla [Line breaks added] Background...

Prevalence, Severity, Concomitant Factors, and Natural Trajectory of Insomnia in Patients with Long COVID Jamie Hansel Robinson, Halle Bakir, Alicia Shanti James, Marquita S. Brooks, Stephen J. Thomas, Kristine L. Lokken Background/Objective Insomnia is a clinically important symptom in Long...

Much more rare than ME/CFS apparently (and opposite sex bias): I saw a few papers that were case reports of sudden onset OCD following COVID. Maybe COVID-related PANS is too rare for anything other assorted case reports. SARS-CoV-2 related paediatric acute-onset neuropsychiatric syndrome...

PANS has to be related to ME/CFS and long COVID, right? Sudden onset of a brain-related condition shortly after any of a number of different infections? The AI summary says it can occur after COVID infection. If so, I'm surprised I haven't really seen it mentioned in any long COVID papers as...

Effect of low dose naltrexone for long covid: a systematic review Oyungerel Byambasuren, Tiffany J Atkins, Shaira Baptista, Paul Glasziou, Samantha Chakraborty [Line breaks added] Background Long covid is a debilitating chronic condition, and the effect of low dose naltrexone (LDN) on its...