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NEGR1 and DCC were the only two genes that were significant in both males and females (using different tests). NEGR1 and DCC also happen to be the genes closest to the 10th and 15th most significant loci in the DecodeME study (though below the genome-wide significance threshold at 1.19e-7 and...

Sex-stratified genome-wide association meta-analysis of major depressive disorder Jodi T. Thomas, Jackson G. Thorp, Floris Huider, Poppy Z. Grimes, Rujia Wang, Pierre Youssef, Jonathan R. I. Coleman, Enda M. Byrne, Mark Adams, BIONIC consortium, The GLAD Study, Sarah E. Medland, Ian B. Hickie...

Stellate Ganglion Block for the Management of Long COVID Symptoms: A Retrospective Cohort Study Michael C. Chiang • Kathryn M. Satko • Christina Shin • Beau P. Sperry • Meghan L. Cabral • Zack Crockett • Richard Gao • Robert J. Yong • Samuel P. Ang • Stacey L. Burns • Alexander J. Kim [Line...

Impressive investigation! It looks they want to appear to be working within Canadian criteria guidance, but if they are really not diagnosing anyone with ME/CFS, they're almost certainly not following the "spirit", or original intent, of the criteria.

On the other hand, we're talking about a disease where proteomics and exercise tests have already been tried several times in less severe people. If there actually are differentially expressed proteins, we expect them to probably have tiny effect sizes, and when you're correcting for a hundred...

The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers Lei Wang, Yujia Xu, Xiang Zhong, Guiping Wang, Zijun Shi, Can Mei, Linwanyue Chen, Jianbo Zhan, Jing Cheng [Line breaks added] Abstract Chronic fatigue syndrome (CFS) is a...

There were some mentions of butyrate in the NIH deep phenotyping study, and in the symposium about the study: ME/CFS Symposium – May 2, 2024 Figure S20D from the study's supplementary info seems to be about the specific bacteria in the gut. It looks like increases and decreases of many...

Yeah, my assumption of how well it would match severity was not based on much data. Just some anecdotes on the forum and knowing that severe/very severe people are known for spending virtually all time lying down. And for myself as probably moderate, I spend most of the time lying down, but I...

The Association of Long COVID and CKD: Findings from the National Clinical Cohort Collaborative (N3C) Anzalone, A. Jerrod1; Krichevsky, Spencer2; Yoo, Yun Jae3; Wilkins, Kenneth J.4; Alakwaa, Fadhl5; Liu, Feifan6; Sakhuja, Ankit7; Saltz, Joel H.8; Han, Yun9; Zhu, Richard L.10; Setoguchi...

I think this might be backwards from what I said. Since lying down includes sleeping, I thought it'd be too much math to try to add up time spent lying down while sleeping plus throughout the day. So instead it's time spent not lying down. So if you are mostly up from when you wake up at 8 AM...

I think most people could estimate hours upright to within about 2 hours. For step count, I personally have almost zero idea how many exact steps I walk. Whenever I try a tracker, I'm surprised by how many steps there are in a short walk around the house.

I wonder if a question about hours of time lying down would be good for future studies. I think either time lying down or step count might be the best indicators of severity we currently have (though step count is probably too difficult for people to estimate without using a tracker). Since the...

Here are all the items (only from UK Biobank analysis) which contain the text "depres" and which were Bonferroni significantly correlated with ME/CFS, with links to descriptions of the items, in order of correlation with highest at the top. The last item is negatively correlated. The most...

The data is available on https://www.macromapqtl.org.uk

If you consider that the prevalence of ME/CFS is far lower than depression, then most people in the depression studies wouldn't have ME/CFS. My sense is that it'd be difficult to get such high correlations based on people in the depression studies having ME/CFS if only a small portion of the...

Yes, just to confirm, the BIGAGWAS website says "9999 represents NA for numerical data".

"Great, maybe people with ME/CFS have a genetic predisposition to unhelpful beliefs. Unfortunately, none of the treatments you have suggested have worked, so lets examine the specific mechanisms through which these genes cause ME/CFS. The genetics seem to be pointing to people with ME/CFS having...

Yes, just sorted by p-value. (And that enormously significant correlation with depression does come from comparing to a study with an enormous sample size: 371,184 depression cases) Good idea to look at top correlations. I wonder what that milk one is about. Just under your significance...