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EBV specifically seems to increase the risk of the neurological damage of MS, so maybe there's some common pathway, even if totally different neurological effects.

Just want to post the following because it slightly goes against the postsynapse specifically part. @hotblack and I managed to get standalone MAGMA working. The results were similar to doing it on FUMA, but not exactly the same (probably because of mapping to rs ids instead of liftover to...

Merged thread ------------------- Exploration of Intersections and Divergences of Long COVID and Chronic Fatigue Syndrome Joao A. Kouyoumdjian, Leticia A. Yamamoto, Carla R. Graca [Line breaks added] Background Fatigue is the most common symptom of Long COVID (LC), defined by persistent or...

Hopefully the full paper describes a placebo control. Otherwise, it seems possible the hand grip strength change is placebo effect.

Oh good point. If I'm understanding correctly, the furthest right, uppermost dot is 20:48914387:T:TA (the lead hit in the whole study), but its MAF is around .34.

They reported the raw p-values. In GWAS, they don't exactly use Bonferroni. It's a convention in GWAS to limit to SNPs with a p-value less than 5x10-8. Revisiting the genome-wide significance threshold for common variant GWAS, 2021

We have this other related thread: Lack of fever during acute infections

Why do you say that? The top hits on chr20 were around that p-value.

I decided to continue this train of thought by testing many different brain datasets. The options are split up by brain region, so I selected a few from each. Of course, I included the five datasets I tested before again so that the multiple test correction would include them. Here is the full...

There are so many stories that the forum software won't let me put them all in one post, so adding more here: LP-Fortellinger (LP-stories) [Continued] Person #13 Person #14 Person #15 Person #16 Person #17 Person #18 Person #19 Person #20

Does pulmonary rehabilitation improve fatigue in patients with post-COVID-19 syndrome? A meta-analysis of randomized clinical trials Laura Pérez-Gisbert, Beatriz Brea-Gómez, Marie Carmen Valenza, Andrés Calvache-Mateo, Araceli Ortiz-Rubio, Irene Torres-Sánchez Purpose To assess the efficacy of...

Papers relating to body temperature and ME/CFS: Dissociation of body‐temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome, 1996 Core body temperature is normal in chronic fatigue syndrome, 1998 - Fukuda Chronic fatigue syndrome and abnormal...

I was interested in monitoring my temperature once. I bought a ~$10 mouth thermometer from the drug store. It was so unprecise. I would measure it three times in a row within seconds of each other, and it'd be a different temperature every time (I think a span of about 1°F). Maybe good for...

We have moved some posts about whether people experience fever as a part of PEM to a new thread: Do you have fever as a part of PEM?

With all due caution regarding my attempt at the MAGMA gene set analysis, I just want to note that there's a further similarity to the Zhang results that might allow us to go a bit further than "synapse" to "postsynapse". The most significant synapse related gene set is specifically...

Posted because this is from the PrecisionLife team who is also working on ME/CFS with their proprietary technique.

Identification and Validation of Novel Combinatorial Genetic Risk Factors for Endometriosis across Multiple UK and US Patient Cohorts JM Sardell, S Das, GL Møller, M Sanna, K Chocian, K Taylor, AR Malinowski, C Stubberfield, A Rochlin, S Gardner Background Endometriosis affects about 10% of...

I thought it might be useful to extend this to more loci than the top 8. Supplementary table 3 has the top 25 loci. Using LocusZoom (online software for uploading and viewing GWAS data that they used in the study), I looked up all of these loci. I combined them in groups of five in the...

Yes, though their evidence for the misrepresentation of symptoms is only the published Reme, Chalder study I quoted, and they don't say too much about this specific point. The following from NICE guidelines evidence review is almost a direct quote from the study. And this is their overall...

While the synapse-related gene sets weren't bonferroni-corrected significant in the DecodeME MAGMA test I did (which I hope to redo with the standalone MAGMA instead of FUMA so that no conversion/data loss is needed), it's striking that it's one of the top gene sets and matches Zhang's finding...