I think even if it was only people with PEM, you should expect that their VO2 and peak power will improve with exercise.
I don't think we have evidence that muscles don't become stronger or the cardiovascular system doesn't become more efficient with training in pwME as opposed to healthy...
Individualised aerobic and resistance exercise training improves exercise tolerance in individuals with Long COVID: findings from the PERCEIVE randomised controlled trial
E Howden, L Burnham, J Smith, K Whitmore, K Morrison, R Hoare, Y Sata, Q Huynh, T Marwick
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Background...
Email newsletter pointed out that there's a page for tips and materials for fundraising on the ME/CFS Research Foundation website: https://mecfs-research.org/en/support/fundraiser/
Human alphaherpesvirus 3 (HHV-3), which was found only in ME/CFS cases, is varicella zoster virus (VZV), AKA chicken pox and shingles.
That's 6/17 people with ME/CFS versus 0/7 healthy controls with this virus.
Letter to the editor and author reply:
Re: Health outcomes of patients in the Complex Chronic Diseases Program
Spencer Cleave, Thea Gilks, Isaac Rodin
Selected paragraphs
"We disagree with the authors’ conclusion that the absence of meaningful clinical improvement in their study indicates...
Previous paper from many of the same authors has a very large overlap in upregulated genes.
From thread paper:
Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients, 2025, Shahbaz et al
Research to evaluate safety and impact of long COVID intervention with Ensitrelvir for National Cohort (RESILIENCE Study): A protocol for a randomized, double-blind, placebo-controlled trial
Konishi, Keiji; Yamamoto, Shungo; Sada, Ryuichi Minoda; Asano, Kento; Onozuka, Daisuke; Tanaka...
“Everything Looks Normal”: Patient Narratives of Contested Legitimacy in Long COVID Medical Encounters
Rhidenour, Kayla B.; Thompson, Charee M.; Babu, Sara; Kelpinski, Lindsay F.
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Abstract
This study examines how individuals with long COVID navigate illness experiences when...
Some might find the slides for these webinars interesting.
Webinar 1: Assessment and Diagnosis
Webinar 2: Managing Common Symptoms and Co-morbidities
Link to main courses page: https://education.emerge.org.au/all-courses/
A Comparative Study of the Coagulation Systems and Inflammatory Profiles of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Patients with Long COVID
Hayley Emma Arron
Supervisor: Prof. Etheresia Pretorius
Stellenbosch University
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Abstract
Myalgic...
Thread for the above study: Blood Flow To The Head Is Reduced in a Patient With Myalgic Encephalomyelitis With Confirmed Post-Exertional Malaise, 2024, Lee
I'm guessing it's this research: Experiences of accessing primary care by those living with long Covid in New Zealand: A qualitative analysis, 2025, Rhodes et al.
Not really equal pressure. If you don't eat food, you will definitely die before too long.
If you don't have energy to hunt or socialize, but live in a tribe, your chances of survival and reproduction might be lessened, but there's still a good chance you survive just fine with others' help...
One possibility, though not sure how valid the argument is:
Should there still be some decrease in appetite long term? At least until one's weight is nearly dangerously low.
Post-Exertional Symptom Exacerbation after Sub-Maximal Exercise in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-Acute Sequelae of COVID-19
Berardi, Giovanni; Janowski, Adam; McNally, Samuel; Post, Andrew; Garg, Alpana; Sluka, Kathleen A.
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