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Just went through this paper, which is quite intense and full of terms I don't understand: Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome I stored all the genes from the text and images that appear to be differentially...

Thanks, yes, that's what I was leaning towards. I didn't know if I should take a purist approach of just accepting whatever authors say, or allowing for a bit of interpretation.

Oh yeah, I plan to do something like that. Figured since it'll mostly be people coming from this thread for now, it's not a big rush, but yep good idea.

I hope you and others can find it useful. The way we've been doing it here of just making a post with all the genes in a thread for a study to be able to search for them is good, but I thought we could probably complement that with a more systematic approach. Oh, I actually try to remove those...

Thank you. In my head, I'm imagining this website as kind of a proof of concept that eventually convinces people who have much more expertise in web development and biomedical research than me to take over or make a better version. I think I can get through all ME/CFS studies on my own in a...

I'm also pretty burned out from coding, so it might take some time for me to add the ability for there to be different users that can add findings.

Current procedure and criteria: Add study First add a study by typing in the DOI, which looks up the rest of the info about the study, then click Save. Add study cohort On the study detail page, click Add study cohort. A study cohort describes the group of interest. For example, if a study...

Theoretically, yeah, I would like to make it so that I can give other people accounts to be able to add studies and genes from those studies. That's the part I'm most nervous about though because of grey areas in deciding what genes make sense to save, and I don't want there to be too much...

It might, but it adds a lot more complexity. Partly because of the added code to write to store that kind of information, but mainly because a single study might find a gene was both up and down in different parts of the study, for example it might be up in the CSF and down in the plasma, so I...

I've looked at 280 studies so far out of about 8000 (completed looking at all studies from 2025 so far), and saved 27 that had gene findings in ME/CFS (includes some older studies like all three IGHV3-30 studies).

For the past month or so I've been working on a project. It's a website for logging genes that were significant from studies on ME/CFS, meant to make it easier to compare genes that are replicated in multiple studies. You can take a look at https://sickgenes.xyz Screenshot: In essence, it's...

You might be interested in this thread as well, which also has links to other related sleep threads: How does exertion affect sleep?

Just pointing out that I don't think (all) people here are necessarily against the idea that sleep dysfunction might be a major component of ME/CFS. Discussion from a while ago...

I will say, these statements about not needing any data because their conclusion is so obvious do appear ridiculous. I can't seem to find the paper. I mean I can find it on Pubmed, but the link to the publisher page is missing. It looks like that was a "Pro" side of a debate. I can find the...

I'm not sure I have the energy to dig too much into papers about this and try to learn about all this stuff like Pcrit. I have no objections to patients trying CPAP or doing more trials (as well blinded as possible and with objective outcomes like actimetry) of CPAP in any of these conditions.

I read the Bluesky thread just now. Isn't the idea that the symptoms in both OSA and snoring would be caused by lack of oxygen while sleeping? I'm not sure I'm seeing what's important about whether it's distinct full apneas or constant narrowness that causes the symptoms. Unrefreshing sleep is...

I see that all but one in the active group had an AHI of at least 5, so at least mild sleep apnea, and two had severe sleep apnea. Out of all the objective measures, it looks like change in AHI was the most significant change compared to sham, which matches with the idea that the CPAP is mainly...

My doctor also had me trial a CPAP (well APAP, which adjusts the pressure automatically) for a few months after a sleep study showed very mild sleep apnea. It made no difference in any way to ME/CFS or anything else.

Interesting idea. I wonder if the CPAP being turned on at night might wake some people up and alert them to it. Or if any people just wake up naturally a few times and would know. Doesn't look like they mention using this method in this study anyway though. Looking at the study, it says at...

I think this is the study: Inspiratory airflow dynamics during sleep in veterans with Gulf War illness: a controlled study (2011, Sleep and Breathing) So is the point that you think CPAP is the treatment for all these conditions? I saw this other study in the Twitter thread: The effect of...