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Copying the figure showing the results of the replication attempt: Significantly increased in both Alkaline phosphatase glucose hba1c leukocyte count neutrophil count triglyceride/HDL-C ratio triglycerides triglyceride glucose index Significantly decreased in both HDL-C

I'm curious why not? Is it concern about long term harm, or the possibility of a bad trip?

I wonder if any of the findings here are worthy of being added to the thread 'What are the top replicated ME/CFS findings?'. I've only read (most of) the paper and haven't followed up on the cited studies. These seem to be the findings they say have been replicated in greater than two studies...

I think I remember some talk about using DXM, another hallucinogen, as a placebo in psychedelic trials for mental health conditions. It's not perfect because the effects are different, so it requires participants who don't have experience with these drugs. Edit: This paper lists potential...

Figure 1. Timeline of treatments and responses for each patient, aligned at moment of first treatment at pain clinic.

Clinical treatment of cluster headache with the serotonergic indoleamine psychedelics psilocybin and LSD and with ketamine: A case series Jonathan Leighton, Carmen Lau, Aisha Savdo, Livia Granata Background Cluster headache is an excruciating condition for which standard treatments are usually...

The study is both about "CFS" and excluded people with "CFS". Similar issue in another paper from Michael Maes:

Neuro-immune and metabolic disorders in association with depression, anxiety, and chronic fatigue-fibromyalgia symptoms due to non-alcoholic fatty liver disease Walaa Abdulhussein Al-Azzawi, Hamid Yaghooti, Hussein Kadhem A-Hakeim, Michael Maes [Line breaks added] Background Nonalcoholic...

On an independent test set?

Figure 1: Median levels of Auto-GPCR Abs in LC vs APC Conclusions Figure 2: SARS-COV-2 specific T cell response to Spike and Nucleocapsid antigens in LC vs APC Figure 3: Correlations between the studied variables

P109 Circulating autoantibodies targeting G-protein-coupled neurotransmitter receptors: reliable biomarkers for long COVID diagnosis? M Camici, M Franco, L Talamanca, E Cimini, E Tartaglia, S Notari, M Petino, L Scarnecchia, A Vergori, R Baldelli, P Zuppi, A Antinori [Line breaks added]...

8: How Stigma Emerges and Mutates: The Case of Long COVID Stigma Hannah Farrimond, Mike Michael [Line breaks added] Introduction How do new stigmas emerge? How do they relate to existing stigma? Why are we seeing an emergent devaluation and discrimination of people who have long COVID, given...

Yeah, the gene is most of the width of the plot, and the x-axis is the position of the SNP on the gene/chromosome. If I look at GeneCards for the location of RAPGEF5 using the GRCh37 assembly which Gene Atlas is using, it says it is located at chr7:22,157,854-22,396,773. The plot goes from...

Sure. I wasn't sure if it'd be better to do all variants at once or per gene. Here is all except PTPRD together, but let me know if you want to see them split by gene: Link Plots: PTPRD CSMD3 RAPGEF5 DCC ALDH18A1 GALNT16 UNC79 NCOA3 Edit: I'll just paste all the variants here for easy copying...

At least all the variants for the genes that replicated in the other cohort show "Pass".

Core features and inherent diversity of post-acute infection syndromes Alain Trautmann [Line breaks added] Abstract Post-acute infection syndromes (PAIS), i.e., long-lasting pathologies subsequent to infections that do not properly resolve, have both a common core and a broad diversity of...

I'm not sure I understand why these warnings relate to this study that looked at new genomes. Is it that the warnings indicate that these positions are hard to read accurately? Doesn't that depend on the sequencing tech?

dbSNP has it: rs1553120233

This is also the same cohort as their previous paper that found Complex V insufficiency. (That paper says 51 participants though, so not exactly the same.) [84] Missailidis, D.; Annesley, S.J.; Allan, C.Y.; Sanislav, O.; Lidbury, B.A.; Lewis, D.P.; Fisher, P.R. An Isolated Complex V...

Considering their control group is just individuals from the general population and they didn't attempt to limit to those without ME/CFS, why would they limit it to 323 individuals? Couldn't they have used a few hundred thousand individuals from a database like the UK BioBank to increase...