They tested 731 phenotypes and reported that 28 were significant and passed their sensitivity analyses. That's 3.83%. Pretty close to the 5% you'd expect to be under p of .05 by random chance. I suspect that a large portion of these are false positives.
Hypothalamic-pituitary-adrenal Axis in Patients Presenting to Psychosomatic Medicine with Fatigue
Sunao Matsubayashi, Makoto Yamashita, Takeshi Hara, Makito Tanabe, Shuichi Matsumoto
Abstract
Many patients with fatigue are referred to psychosomatic medicine, but few studies have examined the...
Serum antineuronal antibodies in patients with post-COVID-19 condition − association to intensive care
Tatiana Posharina, Mikko Varonen, Hanna Jarva, Mari Kanerva, Helena Liira, Sini M Laakso
[Line breaks added]
Highlights
• Antineuronal antibodies found in 12.1% of post-COVID-19 patients...
I'm looking at Supplementary Table 1 where there is a column called pval which matches the p values reported in the paper. They used almost all of the immune cell exposures that were under p<.05 (28/31). There's a p_fdr column where one row is .83 and the rest are over .98. So I'm not really...
Quite a lot of associations. Maybe someone can weave a story out of it.
21. Armstrong CW, Mensah FFK, Leandro MJ, Reddy V, Gooley PR, Berkovitz S, Cambridge G. In vitro B cell experiments explore the role of CD24, CD38, and energy metabolism in ME/CFS. Front Immunol. 2023;14:1178882.
Article...
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