Search results

ME/CFS was defined like this: Figure shows the number of ME/CFS and Long Covid cases over time in the health records:

It seems that the people who sell and promote these brain retraining courses rarely hold a medical degree or have a scientific background. Phil Parker (lightning process) – osteopath Miguel Bautista (CFS recovery) – personal trainer Raelan Agle (Brain Retraining 101) - social work degree Ashok...

I think I know which one you mean: 'ME/CFS & Long Covid Recovery, Support, & Inspiration'. It does include a lot of people enthusiastic about these brain retraining programs. The moderators however, seem to have conflict of interest for selling courses for these programs and often do not have...

903 out of a million is 0.09% so really low.

What is the reasoning or argument behind this? Why should we not be surprised?

The also claim significant effects for hand grip and quality of life but they tested so many variables (including VO2 peak and fatigue severity, which showed no effect) and did not control for multiple testing. The trial design was also A versus A + B, with the control group receiving no...

MCID estimates are a bit imprecise and vague, so not arguing that one is necessarily better than the other. But it seemed that they changed their MCID choice after seeing the data, without explaining this in their paper. The correct way would probably to argue that their result may or may not...

Similar to a previous exercise study found an effect of 36.4 meter on the primary outcome the incremental shuttle walk test. They argue that "The effect size exceeded the minimum clinically important difference of 35.0 m [13]" But in the power calculation in their protocol, they used a minimal...

Now published, see post #9 -------------------------------------------- Abstract Long COVID, reflected by persistent symptoms, including breathlessness and fatigue, after coronavirus disease-19 (COVID-19) infection, presents an unmet therapeutic need. In this study, the effects of a resistance...

Here's the data on the cortical thickness of the brain areas they tested in both groups:

Which is much lower than the 50% that some advocates use (often based on the flawed review linked below): https://www.s4me.info/threads/the-persistence-of-me-cfs-after-sars-cov-2-infection-a-systematic-review-and-meta-analysis-2024-dehlia-et-al.40426/#post-556430

Looked at some of these studies like Li 2022 or Romanet 2023 and they focused on patients discharged from hospital with pulmonary problems so quite different from the ME/CFS subtype of Long Covid.

Don't quite understand what you mean by this? Isn't the problem simply that these trials did not include a non-exercise control group (and thus cannot estimate the effect of exercise)?

Could you give an example?

Cognitive symptoms are one of the required symptoms in many ME/CFS case definitions, so this seems like a circular argument.

There is a new comment by Lillebeth Larun, the primary author: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003200.pub9/detailed-comment/en?messageId=451624933

On Twitter Wigglethemouse also suggested this study as problematic: https://www.ncbi.nlm.nih.gov/pubmed/?term=Kurup+RK%5BAuthor%5D+digoxin%5BTitle%5D And the Perez study using 23 and ME data: Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study 2019...

Ha, that's interesting. So post-exertional malaise became 'submit-exertional malaise'?

Yes it's quite helpful to see the distribution of fatigue scores. The mean was no different between groups: both around 13 which is rather low for the Chalder Fatigue Scale (0-33). In comparison participants of the PACE trial had a score near 28. But the Sars-Cov-2 positives seem to have...

Seems like a very high percentage in Long Covid patients.