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No I don't think so but since the selection of 2 rewards (that were actually paid out) was based on luck, we can look at the mean reward value and see how each participant maximised their actual rewards. This is what I got after a quick calculation. Healthy volunteer F got by far the biggest...

Perhaps because the 4 test trials were still included? Those have a negative trial number and should be removed in the analysis. There is another issue that the rewards that were given are likely those that have a value of 1 for 'Reward_Granted_Yes_is_1' and for 'Successful_Completion_Yes_is_1'...

There is more info on the EEfRT data in this thread: https://www.s4me.info/threads/use-of-eefrt-in-the-nih-study-deep-phenotyping-of-pi-me-cfs-2024-walitt-et-al.37463/page-24#post-520697 Great that you are highlighting this issue. I would like to help out in chat or email to point out the...

These seem to be the main results:

Also from the paper: "Using this symptom scoring system we did not see clear relationships between microclot counts and the presence of symptoms. Around half of the participants had microclot counts similar to the controls but reported the same symptom patterns as those with raised microclots...

Just read this paper. They found a remarkable strong effect for sick leave (GPs recorded sick leave from the participants’ medical records). In the intervention group sick leave dropped from 52% to 25.2%, while in the control group it went from 49.7% to 45.7%.

It is also nearly impossible to discuss this in a rational way because the category is so broad: all long-term somatic symptoms, regardless if they are explained or not. If they claim that 'catastrophising interpretations' or 'somatosensory amplification' are important they can simply point to...

Me too. Very frustrating. So many claims in this article that aren't based on scientific evidence. I suspect some of the Lancet editors and peer reviewers are really biased towards this view otherwise this would never have passed. Take for example statements like these: So a biopsychosocial...

Looks very useful, thanks.

I've posted it in a separate thread here: https://www.s4me.info/threads/the-problems-with-pots-me-cfs-skeptic-blog.39131/

Yes I think the evidence suggests that most patients with ME/CFS have orthostatic intolerance symptoms that are not related to orthostatic tachycardia.

Here's the summary I've posted on Twitter: 1) A new blog post about the problems with Postural Orthostatic Tachycardia Syndrome (POTS) criteria. It’s quite a long read, so I’ll try to summarize the main ideas in this thread. 2) ARGUMENT 1: heart rate increases upon standing > 30 bpm are far...

I've written an overview of the problems with Postural Orthostatic Tachycardia Syndrome (POTS) criteria. https://mecfsskeptic.com/the-problems-with-pots/ A brief summary of the arguments looks like this: A heart rate increase of 30 bpm (or 40 bpm in 12–19-year-olds) is far from abnormal. Many...

Thanks. I've found the Streeten data in his 1987 book which I assume is from the same experiment as the 1988 paper. Orthostatic Disorders of the Circulation: Mechanisms, Manifestations, and ... - David H.P. Streeten - Google Books Interesting paper on diurnal variability. In my view, further...

Thanks. To be honest I don't fully know what to make of it either. Am interested in what others think.

I wrote an overview of the problems I see with the POTS criteria, summarizing the studies posted in this thread. https://mecfsskeptic.com/the-problems-with-pots/ A brief summary of the arguments looks like this: A heart rate increase of 30 bpm (or 40 bpm in 12–19-year-olds) is far from...

Some studies point to this paper by David Streeten as the origin of the 30 bpm threshold for POTS. Unfortunately, I can't seem to find it online. Does anyone have access to it? Abnormal orthostatic changes in blood pressure and heart rate in subjects with intact sympathetic nervous function...

Some quotes from the article:

Abstract Although diagnostic criteria have been developed characterizing postural orthostatic tachycardia syndrome (POTS), no single set of criteria is universally accepted. Furthermore, there are gaps in the present criteria used to identify individuals who have this condition. The...

Interesting to see a ME/CFS study from Russia