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Oh thanks that makes sense. I see that lots of the examples on the beeswarm page are in bins with ties.

I saw they updated the plot to remove the error of 6 positive green dots. But it looks to me like the data is not identical to the previous version. Here is the new figure 2A: I overlaid the new plot over the old plot to compare the y values of the dots. The new ones are to the right, for...

Also in Precision Life's long COVID study: Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis, 2022, Das et al Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis, 2023, Taylor et al But it...

I saw that TASL is also involved in lupus. Just some quotes I grabbed very quickly from abstracts: TASL has a key role in SLE, Nature Reviews Rheumatology, 2025 The role of TASL in the pathogenesis of SLE: X marks the spot, Annals of the Rheumatic Diseases, 2020

Ha thanks. I'll keep reading my intro to genetics book. I do think AI will be providing insights in the future because it already is now. AI means many different things. Precision Life, that works on ME/CFS genetics, says their tools are based on AI. DecodeME even used a machine learning...

Post about World ME Alliance's new resource collection moved to a new thread: Medical Education Hub - World ME Alliance

They say everything to do the study is freely accessible, so it might be something to play around with.

I think the risk alleles were significant after multiple test correction, while the protective alleles were only significant without correction. Risk alleles (pc: corrected p, pnc: not corrected p): Quote about the protective alleles posted above.

Here's the relevant part of that study: Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2020 (thread) So B*08:01 by itself was significantly protective (only when not corrected for multiple tests, p=.01), while the AH8.1 haplotype...

Maybe, but I think it's a bit of a leap from this data. The simplest explanation to me, if the results turned out to be reliable, is that in people with ME/CFS, their HLA/MHC binds less strongly to certain pathogens, and thus less of an adaptive immune response can be raised against the...

For the correlation, I think the sample size of 4 points might be too small to give a reliable p-value. When I test pearson correlation in R with those four points, I get the same result for correlation (0.956) and p-value (.044) as the study got. But when I test the correlation using a...

They specifically looked at these and the two other protective alleles because of the previous study that identified them.

ME/CFS as a sickness behaviour-like response to HSV-1 infection within the brain: A hypothesis John Campbell [Line breaks added] Highlights • Subset of ME/CFS cases proposed to be caused by a ‘noisy’ latent HSV-1 infection within the brain. • HSV-1 proposed to cause local sickness...

Back when researching air purifiers, it seemed Coway had one of the best reputations for more budget-friendly options, so I got their AirMega 150. I always have it on high and it's very loud, so it's in another room. Even a bit of an annoying sound on the lowest setting. I can at least say...

Yes, the two ways I like to think I'd try to get someone to understand how it feels are: in the midst of an awful infection, or immediately after running the longest distance you've ever run. Not exactly the same, but just to illustrate that it's life on "hard mode". Try to live your life...

Some discussion about variants near SUDS3/TAOK3 and their possible relationship to lupus have been moved to: Genetics: Chromosome 12: SUDS3, TAOK3

I might have forgotten or missed something, but why zero in on TLR7? If we're working with the idea of X chromosome dosage, there are lots of other genes that aren't fully silenced on the second X. For example TLR8 right next to it. From another paper: If we're talking about the recent mouse...

Thread for chapter 47: https://www.s4me.info/threads/book-chapter-online-treatment-regimens-in-chronic-fatigue-syndrome-2025-navarette-et-al.45988/

This is the TAOK3/SUDS3 region. The GTEx project shows that variants alter expression differently in different cell types/organs. So I think that's possible. For example, maybe the ME/CFS variant increases TAOK3 in the liver while the SLE variant decreases TAOK3 in the skin, or even alters the...

I'll note that from my amateur attempt to try to determine if both studies share a causal variant at this locus, it doesn't seem like it's the case that they do. First of all, when looking only at the region that includes this locus, chr12:118110000-118470000, there are 344 SNPs that are...