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Direct link to the above article in the Independent And today’s research press release/news item from University of Cambridge https://www.cam.ac.uk/research/news/common-diabetes-drug-and-antihistamine-could-together-repair-multiple-sclerosis-damage-trial-finds And the MS Society who sponsored...

These? Trial info in Norwegian https://www.helse-bergen.no/kliniske-studier/plasmacelle-rettet-behandling-med-daratumumab-ved-mecfs/ English language fundraising page with 3 documents (the two useful ones linked directly below)...

This is a really interesting paper https://pmc.ncbi.nlm.nih.gov/articles/PMC11590279/ Edit: thread on the paper now created here If I’m understanding and summarising correctly, as well as mitochondria being shared from parent to daughter cells, cells can also share mitochondria through...

Thanks @ryanc97 yeah, the papers on the Wikipedia page give a good overview of mechanisms too. And not to say NK and ADDC isn’t the mechanism that is important here, just trying to get a firmer idea of what that is grounded in and how confident we are. And it is perhaps useful to have someone...

That’s been a question I’ve had. Wikipedia quotes a few papers when it says: Do we have a circular argument here that NK cells must be relevant because the mechanism is ADDC and the mechanism must be ADCC because NK cells are relevant? Are other mechanisms just as likely or have I missed something?

Here’s the paper on the phase 1 trial of Bemdaneprocel https://www.nature.com/articles/s41586-025-08845-y And a paper on a phase 1 and 2 trial it seems https://www.nature.com/articles/s41586-025-08700-0 Finally info on the phase 3 trial exPDite-2 https://clinicaltrials.gov/study/NCT06944522...

Great summary @dave30th Thank you. Flabbergasting response from the lead author. They really do seem insistent in thing themselves in knots rather than just saying “yeah, this could have been done better” and withdrawing it.

I first heard about this in a paywalled reuters article More info in this press release from a few days ago Source - Yahoo Finance There’s also a nature article from earlier in he year but it’s also paywalled. And some older items from the company website on this technology. Bayer - Cell...

That sadly sounds like the best approach for anyone that can.

True :) And I really like the constructive attitude you’re describing and are approaching this with. At the same time I’d hate for anyone to get their hopes up and end up being disappointed if things just take as long as they have said it will take. So just wanted to drop that in here. I’ll be...

Doing this properly is essential. I get everyone’s desire for speed, I really do, I want (need) results and treatments ASAP. But most important is that they do this right. This team have trust from people because they know what they’re doing and do things properly. They have set a timetable...

I just heard about this via the BBC article, impressive stuff. Imagine if they could combine things like this with the developments to enable large molecule therapeutics to cross the blood brain barrier.

BIOS-Flash-ME would fit with the basic input and output systems being screwy and needing to be fixed

I found this site useful with reviews of noise cancelling including of the QC Ultras

Do you mean because it’s a part of a subset of the immunoglobulin family it pops up or is there some other reason or link? I’d completely forgotten about the HLA-DQ find.

Not sure if this has been explicitly asked, but does the lack of MHC appearing to be significant in DecodeME results increase the likelihood of whatever is going on being MHC-independent. In other words, should we be looking more at something involving gamma delta T cells, MAIT cells, NK cells...

This would seem a straightforward way of finding out if it is NK cell count or some other factor that is important here. Limit the variables, use the same patients.

Thank you! That’s all really useful.

I don’t as I can’t get out anymore. But probably would if I could. The difference in people’s responses to someone who looks young and healthy but isn’t and someone who is older and looks frail but is fine is telling. People aren’t uncaring, I think, they just don’t know. How much the symbol is...

Thanks for the update @Utsikt It’s a shame they weren’t clearer over the funding, but who knows what uncertainties there have been behind the scenes and well, it’s fantastic they look likely to get all that is needed.