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I think the proposal is more the timing of initiation of PEM after an action which triggers it and then some recovery time if there is no subsequent triggering event? The reference to damage may or may not be directly relevant but gives examples of these timings. I wonder if there could be...

Proof that marathons and ultramarathons are bad for your health! Interesting for the context of physical stress on the body though.

I’ve mainly been in recovery and digest mode. Looks like discussion is moving fast here, I need to catch up. But a couple of thoughts. As it fits in with and expands on much of what we’ve been talking about here in a clear framework, perhaps it’s unsurprising that I really like it. It’s an...

Virus-Induced Endothelial Senescence as a Cause and Driving Factor for ME/CFS and Long COVID: Mediated by a Dysfunctional Immune System Massimo Nunes, Loren Kell, Anouk Slaghekke, Rob Wüst, Burtram Fielding, Douglas Kell, Etheresia Pretorius Abstract Myalgic encephalomyelitis/chronic fatigue...

Haha, I mean, we could… Not using the pipeline I’ve setup though. I’m not sure it’s something I’d want to invest the time in to but… in theory yes we could. Voice cloning has got scarily good.

I’ve now had a first of no doubt many listens. This is great. I really enjoyed it, hope others do and of course most of all hope it gets the right people interested and thinking about the topic. Thanks to the three Jays!

Audio versions are available here https://u.pcloud.link/publink/show?code=kZLPeS5ZBEzVhhjXk8hM18y29vgEGVG6zSvk Any questions, comments or feedback please use this separate thread so we don’t distract from discussion of the paper. Thanks.

I’m sorting an audio version, a few pronunciation questions… “FcγRI” I’m going for “Fc gamma R one” “α1β4 integrin traffic domain”, “Alpha one beta four integrin traffic domain”? “MAIT cells are pronounced “mate” aren’t they? I think most of the others are initialised, things like GDF15, TNF...

That jumped out at me too, my understanding is this is a real thing, or rather the application of quantum mechanics to biology is. But like so much of the world of woo, people have taken it and re or misappropriated language and ideas and... *sigh*

They’re probably confused at all these hits to their archive page… refreshing looking for new papers. At least we know someone has found the admin password and they’re up and running again!

Putting the p value in parsnips?

Nice work @Sasha :thumbup: I’m just doing names for now.. how about Interferon Mediated T-cell Involved Resource Exhausting Disease Yes, I’m Tired

Complex pathways you say… Image source and more information here. Or slightly less scarily ‘what is an interferon?’

Excellent thank you. I can cope with probabilities, greys rather than black and whites. Combinations of complex interactions shifting this or that way. It seems to be how so much in the world works. You’ve often talked about this idea so it makes sense to have it explored more...

Milligan’s Disease as in ‘I told you I was ill” (Ford) "you'd better be prepared for the jump into hyperspace. It's unpleasantly like being drunk." (Arthur) "What's so unpleasant about being drunk?" (Ford) "Ask a glass of water."

Or for more fun maybe we can find something that works for Gimlet or Gimli?

Gamma Receptor, Interferon Mediated, Nociceptor Exciting, Serious Syndrome

There does seem to be a good gap in the publishing archive since last Monday (with just one slipping in on Tuesday). Maybe everyone in the office took the week off? https://www.qeios.com/archive?type=article

Oh well in that case more questions! 1) How would this all fit in with Ryback et al’s findings of increased IGHV3-30 and skewing in the ratio of IgM to IgG BCRs seen in mild/moderate people and not in severe? 2) The basic mechanism seems to be of different cells all doing largely what we’d...

It’s well known that pasties cure all and my hypothalamus definitely has a clock which measures how long since I’ve had one. Or maybe it’s just the swede…