Search results

  1. hotblack

    ME/CFS as a biological information processing problem

    This from another thread but… I was listening to descriptions of neurotransmitters and receptors and this was said Which seemed relevant here, with different people having different effects of drugs, varying symptoms etc. With a neuron having both excitatory and inhibitory receptors, perhaps...
  2. hotblack

    Comparing DNA Methylation Landscapes in Peripheral Blood from [ME/CFS] and Long COVID Patients, 2025, Peppercorn et al

    The platform SequenceME are hoping to use seems to do methylation detection I think. Oxford Nanpore had a conference this week and mentioned it along with other improvements to their platform, I caught some bits of announcements from it, but am not sure of all the details. relevant posts on...
  3. hotblack

    ME/CFS as a biological information processing problem

    With my new found knowledge of what a glial cell is (okay only roughly, at least I know different types exist) I have a question… Which type of glial cell are you thinking of here or more generally with the glial activation idea?
  4. hotblack

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Understandable. I’m sure we all have this concern to varying degrees. There are various things they could and probably will try. But it’s good we have the environment here and some good scientists with which we can explore it. And ultimately I think we’re best served by getting on with good...
  5. hotblack

    Mental activity causing physical PEM, specific symptom patterns?

    Lol, true, and can you imagine how much your jaw would ache after chewing gum? Chewing. For pleasure. Madness!
  6. hotblack

    Mental activity causing physical PEM, specific symptom patterns?

    Definitely does do for me. Everything becomes too much input! What others too have described, does remind me of what it was like early on for me, when I could still watch films, play games etc but within a limit. And it was perhaps more about fatiguability. All beyond me now. But equally I’m...
  7. hotblack

    Closed UK: DecodeME updates, was recruitment thread.

    It is worth contacting them https://www.decodeme.org.uk/faqs/can-i-change-my-consent-choices/
  8. hotblack

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Some of the symptoms for us seem to be the body trying to respond to whatever underlying problem exists. At least that’s what it sometimes feels like. That could explain the paradoxical nature? I also had a period of quite severe depression in my late teens (at least partially triggered by...
  9. hotblack

    Learning about the nervous system

    Different types of neurons and glial cells? What even are they? And how do synapses work? What is a synaptic cleft and action potential? I’ve found the Khan Academy videos and text particularly useful (partially mentioned above) all covering roughly the same information with some variation...
  10. hotblack

    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    My point is about the use dehumanising language particularly on top misunderstandings of other people and in this case cultures and countries. As soon as you take a disagreement and instead dismiss because others are not or are less than human I am concerned we are slipping into dangerous...
  11. hotblack

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    The paper focuses on the genes which may be involved. But the model uses knowledge of protein interactions too. I wonder if it’s possible to get details of which protein interactions were deemed to be important. Can the network be examined to pull out these? I think the paper talks about modules...
  12. hotblack

    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    Maybe we should focus on critiques of content rather than questioning if people are or are not people?
  13. hotblack

    Closed UK: DecodeME updates, was recruitment thread.

    It may be worth seeing my question and Andy’s response in the Zhang paper thread too.
  14. hotblack

    ME/CFS as a biological information processing problem

    Since this has come up a couple of times now. And it’s a very fair counter to my original comment of there being no damage, it is uncertain. However… Do we know if this damage is common? Do we know if any damage is causative of symptoms? Or the result or byproduct of them? Or even unrelated? I...
  15. hotblack

    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    Bravo @Joan Crawford that final sentence was quite the flourish
  16. hotblack

    Mental activity causing physical PEM, specific symptom patterns?

    Two instances of fairly short lived PEM earlier this year that I have some notes from. One from physical activity (sitting up and moving around to cut my hair) another from cognitive/sensory (a very loud and chatty visitor). Both followed similar patterns of aching, more fatigue, feeling ill or...
  17. hotblack

    ME/CFS as a biological information processing problem

    That is fascinating (but also sounds pretty unpleasant!) thanks for explaining @Kitty And thanks for the reading @Snow Leopard much appreciated
  18. hotblack

    Mental activity causing physical PEM, specific symptom patterns?

    For me the thing that changes the most is the underlying trend of how good or bad I am. Then physical or mental triggers are a layer on top of that. Along with all the other changes we have in exactly which set of symptoms or their intensity/duration. I would say there are some differences in...
  19. hotblack

    ME/CFS as a biological information processing problem

    From another thread but relevant to throwing idea around I think After some reading/listening on what happens at synapses during neural activity.. @Kitty are you thinking there is something happening which means once the neuron fires the channels just stay open so neurotransmitters continue to...
  20. hotblack

    News from PrecisionLife Ltd.

    This information has already been posted but it’s relevant to this thread and a bit fragmented when Imwas searching. So to bring it together.. A Press Release from PrecisionLife says First ever confirmation of long COVID genetic associations. This is going to be one of the topics discussed at...
Back
Top Bottom