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Some papers which came up in a search, the first had general background on HLA-C which I found interesting, beyond that maybe someone wiser can decide if they’re relevant HLA-C: evolution, epigenetics, and pathological implications in the major histocompatibility complex Major...

Yeah I absolutely understand both those feelings. I share that, perhaps intellectual curiosity, to get to the bottom of things and really fully understand. And have definitely felt a need for accountability and justice at many times. I’d be surprised if there’s anyone affected who hasn’t. I’m...

All variations which could just as likely a reflection of severity and the complex pathways involved, with different bits switching on/off or interacting up or downstream. I think we discussed this more in another thread recently but forget where. The differences don’t seem to me any greater...

I can understand why some want accountability. For me it’s a waste of energy for something which will get little to nothing in return. My choice is to focus on the present and the future, try to improve things for as many people as possible. That’s still going to be a lot of work but feels...

Back on the HLA-C talk. If I’m understanding this correctly it seems interesting that this is an area involved in the heavy chain given Audrey Ryback’s paper on BCR heavy chain repertoires? The strong linkage disequilibrium may be throwing things off for HLA-C specifically though? If this is...

I’m going to try a definition since this has been coming up a lot recently… Linkage disequilibrium is when at a population scale different segments of DNA, different genetic variations, occur together in different places more or less frequently than you would expect by chance. About right?

Whatever happened to, all the heroes?

HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases Tatsuhiko Naito, Yukinori Okada Abstract Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex region (MHC) significantly affect the risk of...

A couple more papers posted which I found useful understanding a bit more about HLA imputation. Possibly worth understanding a bit about as background in advance of DecodeME papers HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases...

Efficient HLA imputation from sequential SNPs data by transformer Kaho Tanaka, Kosuke Kato, Naoki Nonaka & Jun Seita Abstract Human leukocyte antigen (HLA) genes are associated with a variety of diseases, yet the direct typing of HLA alleles is both time-consuming and costly. Consequently...

Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease. Saori Sakaue, Saisriram Gurajala, Michelle Curtis, Yang Luo, Wanson Choi, Kazuyoshi Ishigaki, Joyce B. Kang, Laurie Rumker, Aaron J. Deutsch, Sebastian Schönherr, Lukas Forer, Jonathon LeFaive, Christian...

Maybe it depends? We don’t all have exactly the same symptoms…

I’m jealous of your laptop :) (and have found even the smaller Gemma3 models and certainly Gemini 2.5 Flash useful for exploring topics and helping me understand roughly what papers or people are talking about at times, not sure asking them to deduce is worth much beyond a bit of fun though)...

Ah, the inappropriate questionnaires will continue until morale improves

They seem to equate fatigue with tiredness, chronic fatigue with tiredness all the time and ME/CFS with tired all the time with a couple of other symptoms. Looking at the papers they reference is very telling, stuff about how people’s partners talked to them and their social support. Here’s the...

I think Kitty makes a really good point. But equally we do need to find ways of supporting good researchers. And how we best do that remains a question to me. Relying upon obstinate sods is not enough, it limits the pool of available talent because not everyone with a sharp and creative mind...

Possibly a bit of a tangent but there was mention on a Financial Times podcast I was listening to of the UK gov looking at attracting teams of scientists from the US and supporting them in getting set up and finding their work in the UK. There seemed to be a particularly focus on...

To be honest I was surprised at some of the responses to start with, but I've found it really useful and informative to talk through them and try to understand concerns. I hope it’ll make me better at making the positive case to others for what we need when I try to. Setting up hubs or...

I’ve been dropping links to resources I’ve found useful in a few threads based upon topic. Different people absorb information in different ways though and different people have different levels of pre existing knowledge. Khan Academy has lots of courses designed exactly to help by providing a...

I’ve always known golf is bad for you