Search results

I did wonder about that, but I don’t think you pursue an NIH grant for a dead duck. And it does seems to have come down to the fact that RE no longer wanted to pursue the work, and he was the expert, as for “too good to be true “– I completely agree. All the more reason for replication,

A few thoughts I don't understand why tenure was quite so big an issue. Every academic wants tenure as it gives them security for the rest of their career. But I think it's unusual to get it very early on, and not getting it quickly doesn't cost you your job - you just don't have job security...

The studies were of viruses in either serum or plasma and didn't look at PBMCs (though you might expect infected PBMCs to shed viruses if the viruses were active) or other possible body reservoirs. Ideally, you would at least look for viruses in PBMCs. Sorry, no idea about peptides or the...

Barbara Stussman of NINDS had previously published an underwhelming Focus group-type study of PEM, though maybe this one - which seems more useful - is part of the same study.

Yes, especially for Bath and Bristol. I’m sure the local presence of Action for. ME is fact as well.

Does anyone know why the areas with the highest prevalence are: Norfolk & Suffolk, Cornwall and the South West? See Fig 1B below, prevalence by ICB (integrated care board - which doesn't align that well with NHS trusts), sex and white/other-than-white Cornwall had Anthony Pinching, consultant...

This paper hasn't been peer-reviewed yet, but I'd like to make a few comments. I think this is the largest ME dataset in the world, with 100,000 people given a diagnostic code of G 93.3 (postal fatigue syndrome, the ICD code that most closely resembles ME, CFS). The F:M ratio of 3.9 isn't too...

Some notes on Jiandi Wan's very interesting presentation Great to have an existing expert in a technical field start working on MEcfs. I think we need much more of this. It makes sense that RBCs are sensitive to local oxygen concentration becoming more flexible and so moving faster through...

#MEA choosing to rely on the CDC study because it is the 'latest data' doesn't sound like the right call to me: we need credible estimates, and at 1.3% this is not: I think we would notice if 1 in 76 people had MEcfs. The CDC data is suspect: 1. It asked people if a medic had told them they had...

Got it now, thanks.

I'm confused. I thought that postural hypotension and POTS could be objectively measured e.g. by the NASA lean test.

These questionnaires are usually used to support Conclusions that patients (including individuals) have objective, physiological, autonomic problems. And I don’t think it’s now safe to draw such conclusions. TBH, I’d always assumed that someone had done this kind of work originally to validate...

Thanks. I struggle to see in such a small study how these findings undermines the idea of a distinction between peripheral and central fatigue.

This is a great topic (I haven't read any of the papers yet). The physiology of pathological fatigue in general isn't well understood (it's not sorted for healthy fatigue either). Presumably, progress in these areas would help the understanding of MEcfs. 1.8. In skeletal muscle physiology...

I can see that as a reason for men to be slower in seeking diagnosis (if it’s true). But most case definitions of ME requires a 50% reduction in functional capacity. If that has happened, which usually means losing your job or reducing hours with huge financial impact, as well as massive impact...

It would take a bit of time, it wouldn’t be too difficult for someone with the right skills. Simply applying Bonferroni to this data, the adjusted value would be 0.00013 (they used two cohorts and only 396 SNPs were common both). The closest value here is 0.0028, more than 20 fold higher...

They screened, 464 SNP’s, and the study make no mention of correcting for the many comparisons (they said they set the value at p less than 0.05: they would be talking about q values if they had corrected for multiple comparisons). This looks like a study of false positives (this team has made...

Thanks. Unfortunately, I don't have the energy to tackle another thread. Do you know if it covers research that addresses the issue of PEM after mental triggers vs PEM after physical ones?

Very true, but I wouldn't expect the same person to experience PEM differently post phy or mental triggers. Especially as PEM is usually seen a (body) global issue, not something localised such as muscle pain This is why I think we new evidence: we know so little about PEM, not least the...

I broadly agree with your very broad and important point, and Occam's Razor is with you. Though I wouldn't completely rule out there being independent types of mental and physical PEM (because a small but significant proportion of pwme have no mental-triggered PEM and some here report mental...