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that was done quite a few years back by both Ron Davis and Ian Lipkin. Null result in both cases, which is probably why neither group public published the work, though the results were shared publicly.

It’s certainly a challenge, but I think we can get somewhere. I don’t know how much T cell, history approach will help if common infections are a trigger (as they appear to be), because most people will have a history of many common infections. Though the T cell work is amazingly cool. And it...

That is the intriguing prospect, though this is a cross-sectional study. I would say the former as my instinct is to believe the patient, particularly when they have a 'don't know' alternative. Plus there is good evidence this is a often a post-infectious illness: Agree that the final option...

Precision Life are an interesting company specialising in computational biology. They have developed a new way of analysing existing genetic data called combinatorial analysis. Instead of looking to see a particular DNA difference is linked with disease, it looks to see if combinations of DNA...

This is an Innovate UK grant, made to speed up the shift from biological findings to drugs by encouraging companies to get involved early and take risks Innovative precision medicine project to diagnose ME/CFS and long Covid more accurately and find the most appropriate treatment options for...

Moved post OXFORD, BRISTOL, EDINBURGH, UK – 15 December 2023 – Leading computational biology company PrecisionLife®, which is driving precision medicine in complex chronic diseases, the ME/CFS charity Action for M.E., and the MRC Human Genetics Unit at the Institute of Genetics and Cancer...

The huge appeal of defects in energy metabolism playing central role is that they can explain the mental as well as the physical fatigue. But they all seem to have the same problem that they can’t explain why a single maximal exercise test produces normal results compared with sedentary...

I agree that it would be great to cross check the answer to the question about being diagnosed with ME/CFS against other data. I don’t know if they have links to respondents‘ health records of permission to access them. As you say, that could improve the question used and the interpretation of...

That is the key question, especially as so much of this paper is speculation, often about weak findings. Yet some of the differences in KP metabolites or their ratios are striking. I now feel better about how much I have been struggling with the biology! I will focus on the key findings and...

What is the true prevalence rate for MEcfs? I agree this prevalence figure will help advocacy, especially in the US. It's a very large (57k), nationally representative study from the CDC and the CDC has put its name to a high prevalence rate for ME/CFS. This will be a real asset for advocacy...

A 1.3% prevalence is 1 in 80 people having a diagnosis. I had always been told that diagnosis was very hard to get in the US. Excluding those we met through this illness, do 1 in 80 people we knew have a diagnosis of ME - maybe 1 in 40 actually having it? I know Charles Shepherd of the MEA...

Massive, representative survey - but red flags too This is a massive, nationally representative survey, which makes this very interesting: There is a lot to go through here, but I am concerned by some mismatches with other data sources and evidence 1. 1.3% is way higher than the Lenny Jason...

:). These days I rely heavily on others, to reduce my pain.

Edited. The abstract doesn't provide any numbers, such as cohort size or results data, so it's impossible to judge if it is worth trying to access a paywalled copy: I thought there were guidelines for writing abstracts - though I think the strongest ones are for clinical trials (CONSORT).

Blue Sky version (shorter and better): https://bsky.app/profile/simonmcg.bsky.social/post/3kdu36ufjbm2n

This is from the same team at PecisionLife that used the same approach in their ME/CFS paper last year (thread, my blog). They are using small cohorts, even allowing for the power of their combinatorial analysis. First, they defined Long Covid cases based on symptoms at 3 months (which is...

More from the MEA Added: note that both groups (biomedical engineering at Sarah University, and Cure ME) have previously found differences in the electrical properties of blood between people with ME. and healthy controls/those with MS. Presumably, this is unpublished data. They...

Can you give an example of this? I haven’t seen any good surveys by health providers

I think this is a very helpful approach, given that it aims a starting point rather than provide definitive Also, it would be interesting to see the comparison between survey results for different proposed treatments. It’s likely that the biases would be similar when the same person is...

How is that not a straightforward reason for the journal to reject the paper? Added: journal information Psych Psych is an international, peer-reviewed, open access journal on psychiatric sciences and psychology, published quarterly online by MDPI.