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What an odd report. Is it a Science report, or a History report? Isn't medical science constantly reinventing aspects of itself because its history is laden with errors? Flat-out whopper mistakes? What if the old studies were biased or based on flawed inferences, etc.? Look at some cancers. At...

That is pretty much my experience as well. Except cognitive can last longer if I've concentrated/focused longer or thought harder, e.g. employed more complex reasoning. But it's pretty quick. Emotion triggers can be even faster and can last longer. Physical typically are delayed about 48 hours...

I am confused by the exertion=exercise assumption. I think I understand their goal: provoke PEM through amplified exertion, and demonstrate that through metabolite comparisons. That sounds reasonable. But how would metabolites come into PEM caused through mental exertion? If PEM=PEM, then...

I've done the 2-day CPET. Here is my problem with it: Unless they bring that bike and mask etc to your house, many of us will be crashing when we do the first CPET. I was. Simply traveling to the research site levied a toll. So I did not say anything, but I know my baseline could not possibly...

"This will involve our current clinical ME/CFS, Chronic Lyme, and Long Covid research project aiming to identify possible causal factors." I'm unclear why some of these researchers like to include Lyme when looking at ME/CFS. More to the point, I'd like to suggest to a possible causal factor...

Fatigue, balance, headaches...they are all "lingering". Lingering like a scent in the air, or a gaze, or a kiss. It's all so... romantic. And implicitly temporary. Researchers on all sides of the endeavor, please stop contributing to the problem with careless wording. These aren't novels you're...

Has any body heard anything about CD57 levels rising with some viruses (e.g EBV and HIV) and declining with certain bacteria (e,g, Lyme and mycoplasma pneumoniae)? I wonder how reliable CD57 is as a marker. Unfortunately, I've seen nothing convincing either proving its utility or disproving it...

@Samuel , my bad. No worries. I am tone deaf when it comes to the written word. Which is why I limit what I post anymore.

? I do similarly. So odd. I can only assume you only assume as to why. Sorry to diverge from thread topic. When your teeth fracture and crumble you are more inclined to flaunt protocol.

Oh sure, I know and I appreciate your insight. I know what lots of key people have suggested over the years, e.g. Peterson and Chia and the New York guy (Cheney's friend) and several other researchers, and the links to EBV and enteroviruses and Herpes etc. I also know how MS started with a psych...

I might suggest that focusing on IM from acute Mono to subsequent ME/CFS diagnosis is not widening the loop, it is narrowing it. And I applaud it, as opposed to his parade of fatigue studies.

Wondering if that i.e. under #2 should be e.g. - if so you could toss the parenthetical "for example".

Genes. Yep. That's important and might prove to be the mechanism. I was thinking more in lines of infectious or specific immune dysfunction. But really infectious. Who's looking these days, and for what, with what? Aren't most focusing soley on symptoms? I hope I am wrong.

It's certainly a big problem, especially if, as some suspect, fatigue is a red herring. Studies are based on definitions. Get the definitions wrong, and the studies could be crap. Of course, in a way this is ass-backwards. Disease definitions should be ultimately drawn from study results, but...

Shouldn't researchers continue looking for causative agent(s)? Or are you suggesting focusing solely on a single symptom at a time, or a single cluster? Am I misunderstanding here? I appreciate diagnostics have failed us, that progress to date has been restrained by the limitations of current...

Well, or observe. It's a step removed from first person. For me it is a reminder of the psychs who co-opted the word from that "sickness behavior" veterinarian. But fair enough.

I wonder how this test is different from vestibular occular tests like the VOR test - which theoretically also can be looking for brain stem issues that translate back to the eyes. And what does she mean by "behavioral" signature? Isn't this more reflexive? It strikes me as an unfortunate...

@Michiel Tack, remember when I advised you needed to cast your epi net further back than you appeared to have done? I was doing some reading yesterday and chanced across this 1990 study of chronic Lyme symptoms. If memory serves me, this would have been right before the real BIG push to...

But not about public tests, ie, NHS/CDC/etc. tests? You do. Large variations in Lyme, too, as well as other tick-borne diseases like babesia.

I agree. If that turns out to be the case. There are so many outstanding unanswered questions and so much white noise generated be pure speculation and nothing more.